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肺障害を指標としたラット過敏反応モデルによる先発および後発パクリタキセル注射液の副作用の比較(発表論文抄録(2012))
https://fukuyama-u.repo.nii.ac.jp/records/8777
https://fukuyama-u.repo.nii.ac.jp/records/8777110eb3c6-5cea-47a5-9ad6-bde405d42249
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
五郎丸剛(発表論文抄録(2012)) (118.7 kB)
|
Copyright (c) 2013 by Fukuyama University
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-12-20 | |||||
| タイトル | ||||||
| タイトル | 肺障害を指標としたラット過敏反応モデルによる先発および後発パクリタキセル注射液の副作用の比較(発表論文抄録(2012)) | |||||
| タイトル | ||||||
| タイトル | Comparison of hypersensitivity to branded and generic paclitaxel injections in rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | HPLC | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 気管支肺胞洗浄液 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 血液ガス分析 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 呼吸困難(化学的誘発,実験的) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 疾患モデル(動物) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 浸透圧 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | タンパク質 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 肺疾患(化学的誘発,実験的) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 肺循環; 血管透過性 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 過敏症-薬物(実験的) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Paclitaxel(毒性・副作用) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 同種医薬品(毒性・副作用) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Sprague-Dawleyラット | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 液体薬剤 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Animals | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Antineoplastic Agents, Phytogenic | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Drug Hypersensitivity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Drugs, Generic | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Hydrogen-Ion Concentration | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Injections | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Male | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Osmotic Pressure | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Paclitaxel | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Pulmonary Edema | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Rats | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Rats, Sprague-Dawley | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
五郎丸, 剛
× 五郎丸, 剛× 守田, 尚史× 長谷, 悠紀× 越智, 良明× 篠原, 義剛× 高橋, 浩二郎× 江藤, 精二 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The use of injectable generic antineoplastic agents has been increasing. Few studies have compared the quality and adverse reactions of generic and branded antineoplastic agents; and therefore, generic agents have not gained wide acceptance. Paclitaxel injections, which are used for treating solid cancers, are being marketed by some companies in Japan. The degree of hypersensitive reactions to these drugs may vary because of the differences in chemical properties of the polyoxyethylene castor oil that is used as a solvent in the paclitaxel preparations. Therefore, we investigated the incidence of pulmonary edema occurring as a hypersensitive reaction in rats administered branded and generic paclitaxel injections. Moreover, we compared the chemical properties of these preparations. We found that the pH of branded and generic paclitaxel preparations diluted with saline was different. This difference in pH may be attributed to a difference in chemical properties from the additive. We observed no significant differences in pulmonary vascular permeability, arterial partial pressure of oxygen, or leakage of protein in the pulmonary alveolus, between paclitaxel preparations administered to rats. These results suggest that both paclitaxel preparations induced pulmonary edema of a similar level in rats, irrespective of the differences in their chemical properties. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The use of injectable generic antineoplastic agents has been increasing. Few studies have compared the quality and adverse reactions of generic and branded antineoplastic agents; and therefore, generic agents have not gained wide acceptance. Paclitaxel injections, which are used for treating solid cancers, are being marketed by some companies in Japan. The degree of hypersensitive reactions to these drugs may vary because of the differences in chemical properties of the polyoxyethylene castor oil that is used as a solvent in the paclitaxel preparations. Therefore, we investigated the incidence of pulmonary edema occurring as a hypersensitive reaction in rats administered branded and generic paclitaxel injections. Moreover, we compared the chemical properties of these preparations. We found that the pH of branded and generic paclitaxel preparations diluted with saline was different. This difference in pH may be attributed to a difference in chemical properties from the additive. We observed no significant differences in pulmonary vascular permeability, arterial partial pressure of oxygen, or leakage of protein in the pulmonary alveolus, between paclitaxel preparations administered to rats. These results suggest that both paclitaxel preparations induced pulmonary edema of a similar level in rats, irrespective of the differences in their chemical properties. | |||||
| 書誌情報 |
福山大学薬学部研究年報 en : Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University 号 31, p. 44-45, 発行日 2013-12-25 |
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| 出版者 | ||||||
| 出版者 | 福山大学薬学部 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0288-724X | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN10064550 | |||||
