{"created":"2023-06-19T09:51:34.487773+00:00","id":8777,"links":{},"metadata":{"_buckets":{"deposit":"4d08ee27-1d86-49a2-9669-0b88af19bde9"},"_deposit":{"created_by":18,"id":"8777","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8777"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008777","sets":["502:503:627:783"]},"author_link":["45338","45916","45919","45670","45671","45918","45917"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"31","bibliographicPageEnd":"45","bibliographicPageStart":"44","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The use of injectable generic antineoplastic agents has been increasing. Few studies have compared the quality and adverse reactions of generic and branded antineoplastic agents; and therefore, generic agents have not gained wide acceptance. Paclitaxel injections, which are used for treating solid cancers, are being marketed by some companies in Japan. The degree of hypersensitive reactions to these drugs may vary because of the differences in chemical properties of the polyoxyethylene castor oil that is used as a solvent in the paclitaxel preparations. Therefore, we investigated the incidence of pulmonary edema occurring as a hypersensitive reaction in rats administered branded and generic paclitaxel injections. Moreover, we compared the chemical properties of these preparations. We found that the pH of branded and generic paclitaxel preparations diluted with saline was different. This difference in pH may be attributed to a difference in chemical properties from the additive. We observed no significant differences in pulmonary vascular permeability, arterial partial pressure of oxygen, or leakage of protein in the pulmonary alveolus, between paclitaxel preparations administered to rats. These results suggest that both paclitaxel preparations induced pulmonary edema of a similar level in rats, irrespective of the differences in their chemical properties.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The use of injectable generic antineoplastic agents has been increasing. Few studies have compared the quality and adverse reactions of generic and branded antineoplastic agents; and therefore, generic agents have not gained wide acceptance. Paclitaxel injections, which are used for treating solid cancers, are being marketed by some companies in Japan. The degree of hypersensitive reactions to these drugs may vary because of the differences in chemical properties of the polyoxyethylene castor oil that is used as a solvent in the paclitaxel preparations. Therefore, we investigated the incidence of pulmonary edema occurring as a hypersensitive reaction in rats administered branded and generic paclitaxel injections. Moreover, we compared the chemical properties of these preparations. We found that the pH of branded and generic paclitaxel preparations diluted with saline was different. This difference in pH may be attributed to a difference in chemical properties from the additive. We observed no significant differences in pulmonary vascular permeability, arterial partial pressure of oxygen, or leakage of protein in the pulmonary alveolus, between paclitaxel preparations administered to rats. These results suggest that both paclitaxel preparations induced pulmonary edema of a similar level in rats, irrespective of the differences in their chemical properties.","subitem_description_type":"Other"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"五郎丸, 剛"}],"nameIdentifiers":[{"nameIdentifier":"45916","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006623806","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006623806"}]},{"creatorNames":[{"creatorName":"守田, 尚史"}],"nameIdentifiers":[{"nameIdentifier":"45917","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014647385","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014647385"}]},{"creatorNames":[{"creatorName":"長谷, 悠紀"}],"nameIdentifiers":[{"nameIdentifier":"45918","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014647386","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014647386"}]},{"creatorNames":[{"creatorName":"越智, 良明"}],"nameIdentifiers":[{"nameIdentifier":"45919","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014646314","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014646314"}]},{"creatorNames":[{"creatorName":"篠原, 義剛"}],"nameIdentifiers":[{"nameIdentifier":"45670","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002858586","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002858586"}]},{"creatorNames":[{"creatorName":"高橋, 浩二郎"}],"nameIdentifiers":[{"nameIdentifier":"45671","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002858591","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002858591"}]},{"creatorNames":[{"creatorName":"江藤, 精二"}],"nameIdentifiers":[{"nameIdentifier":"45338","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002858230","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002858230"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-20"}],"displaytype":"detail","filename":"31-44.pdf","filesize":[{"value":"118.7 kB"}],"format":"application/pdf","license_note":"Copyright (c) 2013 by Fukuyama University","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"五郎丸剛(発表論文抄録(2012))","url":"https://fukuyama-u.repo.nii.ac.jp/record/8777/files/31-44.pdf"},"version_id":"ef747937-ed50-479a-bb03-c9339800f5a1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HPLC","subitem_subject_scheme":"Other"},{"subitem_subject":"気管支肺胞洗浄液","subitem_subject_scheme":"Other"},{"subitem_subject":"血液ガス分析","subitem_subject_scheme":"Other"},{"subitem_subject":"呼吸困難(化学的誘発,実験的)","subitem_subject_scheme":"Other"},{"subitem_subject":"疾患モデル(動物)","subitem_subject_scheme":"Other"},{"subitem_subject":"浸透圧","subitem_subject_scheme":"Other"},{"subitem_subject":"タンパク質","subitem_subject_scheme":"Other"},{"subitem_subject":"肺疾患(化学的誘発,実験的)","subitem_subject_scheme":"Other"},{"subitem_subject":"肺循環; 血管透過性","subitem_subject_scheme":"Other"},{"subitem_subject":"過敏症-薬物(実験的)","subitem_subject_scheme":"Other"},{"subitem_subject":"Paclitaxel(毒性・副作用)","subitem_subject_scheme":"Other"},{"subitem_subject":"同種医薬品(毒性・副作用)","subitem_subject_scheme":"Other"},{"subitem_subject":"Sprague-Dawleyラット","subitem_subject_scheme":"Other"},{"subitem_subject":"液体薬剤","subitem_subject_scheme":"Other"},{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Antineoplastic Agents, Phytogenic","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug Hypersensitivity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drugs, Generic","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hydrogen-Ion Concentration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Injections","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osmotic Pressure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Paclitaxel","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pulmonary Edema","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rats","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rats, Sprague-Dawley","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"肺障害を指標としたラット過敏反応モデルによる先発および後発パクリタキセル注射液の副作用の比較(発表論文抄録(2012))","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肺障害を指標としたラット過敏反応モデルによる先発および後発パクリタキセル注射液の副作用の比較(発表論文抄録(2012))"},{"subitem_title":"Comparison of hypersensitivity to branded and generic paclitaxel injections in rats","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["783"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-20"},"publish_date":"2017-12-20","publish_status":"0","recid":"8777","relation_version_is_last":true,"title":["肺障害を指標としたラット過敏反応モデルによる先発および後発パクリタキセル注射液の副作用の比較(発表論文抄録(2012))"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:17:09.308651+00:00"}