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ニコチン受容体を標的とした統合失調症治療薬の可能性(発表論文抄録(2009))
https://fukuyama-u.repo.nii.ac.jp/records/8589
https://fukuyama-u.repo.nii.ac.jp/records/8589d2db5f31-930f-4b75-b1a0-e8ecae87d836
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ニコチン受容体を標的とした統合失調症治療薬の可能性 (498.7 kB)
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Copyright (c) 2010 by Fukuyama University
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-01-27 | |||||
| タイトル | ||||||
| タイトル | ニコチン受容体を標的とした統合失調症治療薬の可能性(発表論文抄録(2009)) | |||||
| タイトル | ||||||
| タイトル | Nicotinic Acetylcholine Receptors are Possible Therapeutic Targets for Schizophrenia | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | α7 nicotinic acetylcholine receptor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | schizophrenia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | prepulse inhibition | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dopamine | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | α_7 nicotinic acetylcholine receptor | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | schizophrenia | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | prepulse inhibition | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | dopamine | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
鴻海, 俊太郎
× 鴻海, 俊太郎× 末丸, 克矢× 川崎, 博己× 町支, 臣成× 日比野, 俐× 荒木, 博陽 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 45294 | |||||
| 姓名 | KOHNOMI, Shuntaro | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 45295 | |||||
| 姓名 | SUEMARU, Katsuya | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 45296 | |||||
| 姓名 | KAWASAKI, Hiromu | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 45297 | |||||
| 姓名 | CHOSHI, Tominari | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 45298 | |||||
| 姓名 | HIBINO, Satoshi | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 45299 | |||||
| 姓名 | ARAKI, Hiroaki | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The rate of smoking in patients with schizophrenia is higher than that in the general population. Nicotinic acetylcholine receptors (nAChR) are involved in the sensorimotor gating deficits in schizophrenia. We have revealed that nicotine ameliorates the disruption of the PPI, a model of sensorimotor gating, which is induced by apomorphine, a dopamine receptor agonist, but is not effective for the disruption of the PPI induced by phencyclidine, a glutamine NMDA receptor antagonist, in rats. Furthermore, the ameliorating effect of nicotine is antagonized by methyllycaconitine, a selective α_7 nAChR antagonist. The effect of nocitine was also investigated in the stereotyped behavior induced by apomorphine, however, nicotine was found to have no significant effect. Considering these results, the ameliorating effect of the disruption of the PPI via α_7 nAChR is therefore thought to be involved in dopaminergic systems. The dopaminergic systems involved in α_7 nAChR may be different from the systems involved in stereotypy. In addition, this review describes the effects of the α_7 nicotinic receptor agonists. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The rate of smoking in patients with schizophrenia is higher than that in the general population. Nicotinic acetylcholine receptors (nAChR) are involved in the sensorimotor gating deficits in schizophrenia. We have revealed that nicotine ameliorates the disruption of the PPI, a model of sensorimotor gating, which is induced by apomorphine, a dopamine receptor agonist, but is not effective for the disruption of the PPI induced by phencyclidine, a glutamine NMDA receptor antagonist, in rats. Furthermore, the ameliorating effect of nicotine is antagonized by methyllycaconitine, a selective α_7 nAChR antagonist. The effect of nocitine was also investigated in the stereotyped behavior induced by apomorphine, however, nicotine was found to have no significant effect. Considering these results, the ameliorating effect of the disruption of the PPI via α_7 nAChR is therefore thought to be involved in dopaminergic systems. The dopaminergic systems involved in α_7 nAChR may be different from the systems involved in stereotypy. In addition, this review describes the effects of the α_7 nicotinic receptor agonists. | |||||
| 書誌情報 |
福山大学薬学部研究年報 en : Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University 号 28, p. 36-37, 発行日 2010-12-25 |
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| 出版者 | ||||||
| 出版者 | 福山大学薬学部 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0288-724X | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN10064550 | |||||
