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同位体分離法による合成麻薬性鎮痛薬フェンタニルの同位体希釈分析法の開発とその応用
https://fukuyama-u.repo.nii.ac.jp/records/7064
https://fukuyama-u.repo.nii.ac.jp/records/7064d8461528-356a-4a32-8da2-d84641325af7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00005784661.pdf (1.1 MB)
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| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 1998-01-01 | |||||
| タイトル | ||||||
| タイトル | 同位体分離法による合成麻薬性鎮痛薬フェンタニルの同位体希釈分析法の開発とその応用 | |||||
| タイトル | ||||||
| タイトル | Development and application of isotope dilution analysis for fentanyl by isotopic fractionation. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 記事種別(日) | ||||||
| 値 | 総説 | |||||
| 著者名(日) |
世良, 庄司
× 世良, 庄司 |
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| 著者名よみ | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 36511 | |||||
| 姓名 | セラ, ショウジ | |||||
| 著者名(英) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 36512 | |||||
| 姓名 | Sera, Shoji | |||||
| 言語 | en | |||||
| 著者所属(日) | ||||||
| 値 | 福山大学薬学部 | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | FACULTY OF PHARMACY & PHARMACEUTICAL SCIENCES FUKUYAMA UNIVERSITY | |||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Advantages of isotope dillution analysis for fentanyl (FT) and its main metabolite, norfentanyl (Nor-FT) were demonstrated. Isotopic fractionation for isotope dillution analysis was examined by separation of FT and its deuterated analogue using capillary gas chromatograph. The separation of FT and seven kinds of deuterated FTs were proportional to the number of labeled deuterium atoms and inversely to the temperature of the column oven. The propionyl group was more effectively position of deuterium labeling for isotopic fractionation than anilino or phenylethyl groups. The quantitative determination of FT in serum and urine was examined by GC equipped with a surface ionization detector (SID) . For an analysis of Nor-FT -in urine, N-alkylation was necessary to detect sensitively by SID. Methyl derivative was selected from 3 kinds of N-alkyl derivatives to increase sensitivity and peak resolution, and to prevent interference with urinary compound. No endogenous compounds or concomitant drugs interfered with the detection of FT and Nor-FT in the serum or the urine of patients. Furthermore, pharmacokinetics of FT was solved with the present method by two-compartment model built into metabolic process. | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN10064550 | |||||
| 書誌情報 |
福山大学薬学部研究年報 en : Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University 巻 16, p. 1-25, 発行日 1998 |
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