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慢性腎不全モデルラットにおけるキトサンの抗酸化及び腎保護効果(発表論文抄録(2012))
https://fukuyama-u.repo.nii.ac.jp/records/8772
https://fukuyama-u.repo.nii.ac.jp/records/87724cbe0639-fff8-4712-9d4c-a1cc485f5d3f
名前 / ファイル | ライセンス | アクション |
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安楽誠(発表論文抄録(2012)) (132.9 kB)
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Copyright (c) 2013 by Fukuyama University
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-12-20 | |||||
タイトル | ||||||
タイトル | 慢性腎不全モデルラットにおけるキトサンの抗酸化及び腎保護効果(発表論文抄録(2012)) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Antioxidant and renoprotective activity of chitosan in nephrectomized rats. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Animals | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Antioxidants | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Chitosan | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Indican | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Iron | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Kidney Failure, Chronic | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Male | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Nephrectomy | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Oxidation-Reduction | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Oxidative Stress | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Rats | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Serum Albumin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Anraku, Makoto
× Anraku, Makoto× Tomida, Hisao× Michihara, Akihiro× Tsuchiya, Daiju× Iohara, Daisuke× Maezaki, Yuji× Uekama, Kaneto× Maruyama, Toru× Otagiri, Masaki× Hirayama, Fumitoshi |
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著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 45124 | |||||
識別子Scheme | CiNii ID | |||||
識別子URI | http://ci.nii.ac.jp/nrid/9000003077192 | |||||
識別子 | 9000003077192 | |||||
姓名 | 安楽, 誠 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 45166 | |||||
識別子Scheme | CiNii ID | |||||
識別子URI | http://ci.nii.ac.jp/nrid/9000005174459 | |||||
識別子 | 9000005174459 | |||||
姓名 | 冨田, 久夫 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 45113 | |||||
識別子Scheme | CiNii ID | |||||
識別子URI | http://ci.nii.ac.jp/nrid/9000014625611 | |||||
識別子 | 9000014625611 | |||||
姓名 | 道原, 明宏 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 45909 | |||||
識別子Scheme | CiNii ID | |||||
識別子URI | http://ci.nii.ac.jp/nrid/9000279914318 | |||||
識別子 | 9000279914318 | |||||
姓名 | 土谷, 大樹 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 45866 | |||||
識別子Scheme | CiNii ID | |||||
識別子URI | http://ci.nii.ac.jp/nrid/9000279908736 | |||||
識別子 | 9000279908736 | |||||
姓名 | 庵原, 大輔 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 45867 | |||||
識別子Scheme | CiNii ID | |||||
識別子URI | http://ci.nii.ac.jp/nrid/9000018772491 | |||||
識別子 | 9000018772491 | |||||
姓名 | 前崎, 祐二 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 45868 | |||||
識別子Scheme | CiNii ID | |||||
識別子URI | http://ci.nii.ac.jp/nrid/1000090040328 | |||||
識別子 | 1000090040328 | |||||
姓名 | 上釜, 兼人 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 45217 | |||||
識別子Scheme | CiNii ID | |||||
識別子URI | http://ci.nii.ac.jp/nrid/9000002749091 | |||||
識別子 | 9000002749091 | |||||
姓名 | 丸山, 徹 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 45218 | |||||
識別子Scheme | CiNii ID | |||||
識別子URI | http://ci.nii.ac.jp/nrid/1000080120145 | |||||
識別子 | 1000080120145 | |||||
姓名 | 小田切, 優樹 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 45869 | |||||
識別子Scheme | CiNii ID | |||||
識別子URI | http://ci.nii.ac.jp/nrid/1000090094036 | |||||
識別子 | 1000090094036 | |||||
姓名 | 平山, 文俊 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The effect of chitosan on oxidative stress and chronic renal failure was investigated using 5/6 nephrectomized rats. The ingestion of chitosan over a 4-week period resulted in a significant decrease in total body weight, glucose, serum creatinine and indoxyl sulfate levels (P=0.0011, P=0.0006, P=0.0012, and P=0.0005, respectively), compared with the non-treated nephrectomized group. The ingestion of chitosan also resulted in a lowered ratio of oxidized to reduced albumin (P=0.003) and an increase in biological antioxidant potential (P=0.023). Interestingly, the oxidized albumin ratio was correlated with serum indoxyl sulfate levels in vivo. These results suggest that the ingestion of chitosan results in a significant reduction in the levels of pro-oxidants, such as uremic toxins, in the gastrointestinal tract, thereby inhibiting the subsequent development of oxidative stress in the systemic circulation. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The effect of chitosan on oxidative stress and chronic renal failure was investigated using 5/6 nephrectomized rats. The ingestion of chitosan over a 4-week period resulted in a significant decrease in total body weight, glucose, serum creatinine and indoxyl sulfate levels (P=0.0011, P=0.0006, P=0.0012, and P=0.0005, respectively), compared with the non-treated nephrectomized group. The ingestion of chitosan also resulted in a lowered ratio of oxidized to reduced albumin (P=0.003) and an increase in biological antioxidant potential (P=0.023). Interestingly, the oxidized albumin ratio was correlated with serum indoxyl sulfate levels in vivo. These results suggest that the ingestion of chitosan results in a significant reduction in the levels of pro-oxidants, such as uremic toxins, in the gastrointestinal tract, thereby inhibiting the subsequent development of oxidative stress in the systemic circulation. | |||||
書誌情報 |
福山大学薬学部研究年報 en : Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University 号 31, p. 36-36, 発行日 2013-12-25 |
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出版者 | ||||||
出版者 | 福山大学薬学部 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0288-724X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10064550 |