{"created":"2023-06-19T09:51:34.265507+00:00","id":8772,"links":{},"metadata":{"_buckets":{"deposit":"8b0e487a-87bc-4b6b-af07-e0357c161488"},"_deposit":{"created_by":18,"id":"8772","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8772"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008772","sets":["502:503:627:783"]},"author_link":["45864","45124","45866","45860","45166","45858","45863","45867","45861","45868","45859","45856","45113","45862","45869","45218","45855","45217","45857","45909"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"31","bibliographicPageEnd":"36","bibliographicPageStart":"36","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effect of chitosan on oxidative stress and chronic renal failure was investigated using 5/6 nephrectomized rats. The ingestion of chitosan over a 4-week period resulted in a significant decrease in total body weight, glucose, serum creatinine and indoxyl sulfate levels (P=0.0011, P=0.0006, P=0.0012, and P=0.0005, respectively), compared with the non-treated nephrectomized group. The ingestion of chitosan also resulted in a lowered ratio of oxidized to reduced albumin (P=0.003) and an increase in biological antioxidant potential (P=0.023). Interestingly, the oxidized albumin ratio was correlated with serum indoxyl sulfate levels in vivo. These results suggest that the ingestion of chitosan results in a significant reduction in the levels of pro-oxidants, such as uremic toxins, in the gastrointestinal tract, thereby inhibiting the subsequent development of oxidative stress in the systemic circulation.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The effect of chitosan on oxidative stress and chronic renal failure was investigated using 5/6 nephrectomized rats. The ingestion of chitosan over a 4-week period resulted in a significant decrease in total body weight, glucose, serum creatinine and indoxyl sulfate levels (P=0.0011, P=0.0006, P=0.0012, and P=0.0005, respectively), compared with the non-treated nephrectomized group. The ingestion of chitosan also resulted in a lowered ratio of oxidized to reduced albumin (P=0.003) and an increase in biological antioxidant potential (P=0.023). Interestingly, the oxidized albumin ratio was correlated with serum indoxyl sulfate levels in vivo. These results suggest that the ingestion of chitosan results in a significant reduction in the levels of pro-oxidants, such as uremic toxins, in the gastrointestinal tract, thereby inhibiting the subsequent development of oxidative stress in the systemic circulation.","subitem_description_type":"Other"}]},"item_10002_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"45124","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000003077192","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000003077192"}],"names":[{"name":"安楽, 誠"}]},{"nameIdentifiers":[{"nameIdentifier":"45166","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005174459","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005174459"}],"names":[{"name":"冨田, 久夫"}]},{"nameIdentifiers":[{"nameIdentifier":"45113","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014625611","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014625611"}],"names":[{"name":"道原, 明宏"}]},{"nameIdentifiers":[{"nameIdentifier":"45909","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000279914318","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000279914318"}],"names":[{"name":"土谷, 大樹"}]},{"nameIdentifiers":[{"nameIdentifier":"45866","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000279908736","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000279908736"}],"names":[{"name":"庵原, 大輔"}]},{"nameIdentifiers":[{"nameIdentifier":"45867","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000018772491","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000018772491"}],"names":[{"name":"前崎, 祐二"}]},{"nameIdentifiers":[{"nameIdentifier":"45868","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090040328","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000090040328"}],"names":[{"name":"上釜, 兼人"}]},{"nameIdentifiers":[{"nameIdentifier":"45217","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002749091","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002749091"}],"names":[{"name":"丸山, 徹"}]},{"nameIdentifiers":[{"nameIdentifier":"45218","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000080120145","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000080120145"}],"names":[{"name":"小田切, 優樹"}]},{"nameIdentifiers":[{"nameIdentifier":"45869","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090094036","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000090094036"}],"names":[{"name":"平山, 文俊"}]}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Anraku, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"45855","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomida, Hisao"}],"nameIdentifiers":[{"nameIdentifier":"45856","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Michihara, Akihiro"}],"nameIdentifiers":[{"nameIdentifier":"45857","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuchiya, Daiju"}],"nameIdentifiers":[{"nameIdentifier":"45858","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iohara, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"45859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maezaki, Yuji"}],"nameIdentifiers":[{"nameIdentifier":"45860","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uekama, Kaneto"}],"nameIdentifiers":[{"nameIdentifier":"45861","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maruyama, Toru"}],"nameIdentifiers":[{"nameIdentifier":"45862","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Otagiri, Masaki"}],"nameIdentifiers":[{"nameIdentifier":"45863","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirayama, Fumitoshi"}],"nameIdentifiers":[{"nameIdentifier":"45864","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-20"}],"displaytype":"detail","filename":"31-36.pdf","filesize":[{"value":"132.9 kB"}],"format":"application/pdf","license_note":"Copyright (c) 2013 by Fukuyama University","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"安楽誠(発表論文抄録(2012))","url":"https://fukuyama-u.repo.nii.ac.jp/record/8772/files/31-36.pdf"},"version_id":"9cde924e-0b0e-4351-bf8e-8f4eb1140a78"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Antioxidants","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chitosan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Indican","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Iron","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Kidney Failure, Chronic","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nephrectomy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidation-Reduction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidative Stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rats","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Serum Albumin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin 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