WEKO3
インデックスリンク
アイテム
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Caco-2細胞におけるN-アセチル5-アミノサルチル酸の透過に及ぼすケセルセチンの影響(発表論文抄録(2013))
https://fukuyama-u.repo.nii.ac.jp/records/8739
https://fukuyama-u.repo.nii.ac.jp/records/87398a84ee4e-e8bf-4240-82c9-8de4f2069d38
名前 / ファイル | ライセンス | アクション |
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上敷領淳(発表論文抄録(2013)) (155.2 kB)
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Copyright (c) 2014 by Fukuyama University
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-12-18 | |||||
タイトル | ||||||
タイトル | Caco-2細胞におけるN-アセチル5-アミノサルチル酸の透過に及ぼすケセルセチンの影響(発表論文抄録(2013)) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effect of quercetin on the permeability of N-acetyl 5-aminosalicylic acid on Caco-2 cells. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Aminosalicylic Acids | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Biological Transport | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Caco-2 Cells | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Drug Interactions | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Humans | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Mitoxantrone | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Multidrug Resistance-Associated Proteins | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Propionates | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Quercetin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Quinidine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Quinolines | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Kamishikiryo, Jun
× Kamishikiryo, Jun× Matsumura, Ryusuke× Takamori, Tomohiro× Sugihara, Narumi |
|||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 45648 | |||||
識別子Scheme | CiNii ID | |||||
識別子URI | http://ci.nii.ac.jp/nrid/9000279914332 | |||||
識別子 | 9000279914332 | |||||
姓名 | 上敷領, 淳 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 45649 | |||||
識別子Scheme | CiNii ID | |||||
識別子URI | http://ci.nii.ac.jp/nrid/9000342904997 | |||||
識別子 | 9000342904997 | |||||
姓名 | 松村, 隆介 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 45650 | |||||
姓名 | 高森, 智敬 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 45118 | |||||
識別子Scheme | CiNii ID | |||||
識別子URI | http://ci.nii.ac.jp/nrid/9000005187246 | |||||
識別子 | 9000005187246 | |||||
姓名 | 杉原, 成美 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The aim of this study was to investigate the transporter-mediated transport of N-acetyl 5-aminosalicylic acid (Ac-5-ASA) and the effect of quercetin on Ac-5-ASA transport. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Caco-2 cell monolayers grown in Transwells were used to study the transport of Ac-5-ASA in the absence or presence of quercetin, and apical-to-basolateral and basolateral-to-apical apparent permeability (PappAB and PappBA values, respectively) was determined. The effect of transporter inhibitors, such as MK571, quinidine and mitoxantrone, on the transport of Ac-5-ASA was investigated. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In the absence of transporter mediators, the transport of Ac-5-ASA was much higher in the basolateral-to-apical direction than in the opposite direction. The PappBA/PappAB ratio of Ac-5-ASA was 4.89. Quercetin inhibited the apical efflux of Ac-5-ASA and decreased the PappBA/PappAB ratio to 1.05. Of the transporter inhibitors, MK571 decreased the PappBA/PappAB ratio to 1.07; however, neither quinidine nor mitoxantrone had an effect on Ac-5-ASA transport. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Ac-5-ASA was excreted by multidrug resistance-associated protein 2 from Caco-2 cells, and its transport was inhibited by quercetin. Our findings suggest that dose levels of sulfasalazine or 5-aminosalicylic acid can be decreased by coadministration of quercetin, leading to improved pharmaceutical care for inflammatory bowel diseases. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The aim of this study was to investigate the transporter-mediated transport of N-acetyl 5-aminosalicylic acid (Ac-5-ASA) and the effect of quercetin on Ac-5-ASA transport. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Caco-2 cell monolayers grown in Transwells were used to study the transport of Ac-5-ASA in the absence or presence of quercetin, and apical-to-basolateral and basolateral-to-apical apparent permeability (PappAB and PappBA values, respectively) was determined. The effect of transporter inhibitors, such as MK571, quinidine and mitoxantrone, on the transport of Ac-5-ASA was investigated. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | In the absence of transporter mediators, the transport of Ac-5-ASA was much higher in the basolateral-to-apical direction than in the opposite direction. The PappBA/PappAB ratio of Ac-5-ASA was 4.89. Quercetin inhibited the apical efflux of Ac-5-ASA and decreased the PappBA/PappAB ratio to 1.05. Of the transporter inhibitors, MK571 decreased the PappBA/PappAB ratio to 1.07; however, neither quinidine nor mitoxantrone had an effect on Ac-5-ASA transport. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Ac-5-ASA was excreted by multidrug resistance-associated protein 2 from Caco-2 cells, and its transport was inhibited by quercetin. Our findings suggest that dose levels of sulfasalazine or 5-aminosalicylic acid can be decreased by coadministration of quercetin, leading to improved pharmaceutical care for inflammatory bowel diseases. | |||||
書誌情報 |
福山大学薬学部研究年報 en : Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University 号 32, p. 28-28, 発行日 2014-12-25 |
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出版者 | ||||||
出版者 | 福山大学薬学部 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0288-724X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10064550 |