{"created":"2023-06-19T09:51:32.848333+00:00","id":8739,"links":{},"metadata":{"_buckets":{"deposit":"d212f79b-bd99-487d-9945-1206c6a72277"},"_deposit":{"created_by":18,"id":"8739","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8739"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008739","sets":["502:503:627:782"]},"author_link":["45644","45646","45647","45650","45645","45118","45648","45649"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"32","bibliographicPageEnd":"28","bibliographicPageStart":"28","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of this study was to investigate the transporter-mediated transport of N-acetyl 5-aminosalicylic acid (Ac-5-ASA) and the effect of quercetin on Ac-5-ASA transport.","subitem_description_type":"Abstract"},{"subitem_description":"Caco-2 cell monolayers grown in Transwells were used to study the transport of Ac-5-ASA in the absence or presence of quercetin, and apical-to-basolateral and basolateral-to-apical apparent permeability (PappAB and PappBA values, respectively) was determined. The effect of transporter inhibitors, such as MK571, quinidine and mitoxantrone, on the transport of Ac-5-ASA was investigated.","subitem_description_type":"Abstract"},{"subitem_description":"In the absence of transporter mediators, the transport of Ac-5-ASA was much higher in the basolateral-to-apical direction than in the opposite direction. The PappBA/PappAB ratio of Ac-5-ASA was 4.89. Quercetin inhibited the apical efflux of Ac-5-ASA and decreased the PappBA/PappAB ratio to 1.05. Of the transporter inhibitors, MK571 decreased the PappBA/PappAB ratio to 1.07; however, neither quinidine nor mitoxantrone had an effect on Ac-5-ASA transport.","subitem_description_type":"Abstract"},{"subitem_description":"Ac-5-ASA was excreted by multidrug resistance-associated protein 2 from Caco-2 cells, and its transport was inhibited by quercetin. Our findings suggest that dose levels of sulfasalazine or 5-aminosalicylic acid can be decreased by coadministration of quercetin, leading to improved pharmaceutical care for inflammatory bowel diseases.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The aim of this study was to investigate the transporter-mediated transport of N-acetyl 5-aminosalicylic acid (Ac-5-ASA) and the effect of quercetin on Ac-5-ASA transport.","subitem_description_type":"Other"},{"subitem_description":"Caco-2 cell monolayers grown in Transwells were used to study the transport of Ac-5-ASA in the absence or presence of quercetin, and apical-to-basolateral and basolateral-to-apical apparent permeability (PappAB and PappBA values, respectively) was determined. The effect of transporter inhibitors, such as MK571, quinidine and mitoxantrone, on the transport of Ac-5-ASA was investigated.","subitem_description_type":"Other"},{"subitem_description":"In the absence of transporter mediators, the transport of Ac-5-ASA was much higher in the basolateral-to-apical direction than in the opposite direction. The PappBA/PappAB ratio of Ac-5-ASA was 4.89. Quercetin inhibited the apical efflux of Ac-5-ASA and decreased the PappBA/PappAB ratio to 1.05. Of the transporter inhibitors, MK571 decreased the PappBA/PappAB ratio to 1.07; however, neither quinidine nor mitoxantrone had an effect on Ac-5-ASA transport.","subitem_description_type":"Other"},{"subitem_description":"Ac-5-ASA was excreted by multidrug resistance-associated protein 2 from Caco-2 cells, and its transport was inhibited by quercetin. Our findings suggest that dose levels of sulfasalazine or 5-aminosalicylic acid can be decreased by coadministration of quercetin, leading to improved pharmaceutical care for inflammatory bowel diseases.","subitem_description_type":"Other"}]},"item_10002_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"45648","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000279914332","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000279914332"}],"names":[{"name":"上敷領, 淳"}]},{"nameIdentifiers":[{"nameIdentifier":"45649","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000342904997","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000342904997"}],"names":[{"name":"松村, 隆介"}]},{"nameIdentifiers":[{"nameIdentifier":"45650","nameIdentifierScheme":"WEKO"}],"names":[{"name":"高森, 智敬"}]},{"nameIdentifiers":[{"nameIdentifier":"45118","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005187246","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005187246"}],"names":[{"name":"杉原, 成美"}]}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kamishikiryo, Jun"}],"nameIdentifiers":[{"nameIdentifier":"45644","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumura, Ryusuke"}],"nameIdentifiers":[{"nameIdentifier":"45645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takamori, Tomohiro"}],"nameIdentifiers":[{"nameIdentifier":"45646","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugihara, Narumi"}],"nameIdentifiers":[{"nameIdentifier":"45647","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-18"}],"displaytype":"detail","filename":"32-28.pdf","filesize":[{"value":"155.2 kB"}],"format":"application/pdf","license_note":"Copyright (c) 2014 by Fukuyama University","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"上敷領淳(発表論文抄録(2013))","url":"https://fukuyama-u.repo.nii.ac.jp/record/8739/files/32-28.pdf"},"version_id":"c11b7819-db7a-41f8-a2ec-6c46ee76da6f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Aminosalicylic Acids","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Biological Transport","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Caco-2 Cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug Interactions","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mitoxantrone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Multidrug Resistance-Associated Proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Propionates","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Quercetin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Quinidine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Quinolines","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Caco-2細胞におけるN-アセチル5-アミノサルチル酸の透過に及ぼすケセルセチンの影響(発表論文抄録(2013))","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Caco-2細胞におけるN-アセチル5-アミノサルチル酸の透過に及ぼすケセルセチンの影響(発表論文抄録(2013))"},{"subitem_title":"Effect of quercetin on the permeability of N-acetyl 5-aminosalicylic acid on Caco-2 cells.","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["782"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-18"},"publish_date":"2017-12-18","publish_status":"0","recid":"8739","relation_version_is_last":true,"title":["Caco-2細胞におけるN-アセチル5-アミノサルチル酸の透過に及ぼすケセルセチンの影響(発表論文抄録(2013))"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:17:59.866394+00:00"}