{"created":"2023-06-19T09:51:37.621986+00:00","id":8849,"links":{},"metadata":{"_buckets":{"deposit":"0fc14c05-db38-458f-b3b8-e6fb0adbaf4c"},"_deposit":{"created_by":18,"id":"8849","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8849"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008849","sets":["502:503:627:764"]},"author_link":["46338","46336","46337","46335"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"29","bibliographicPageEnd":"63","bibliographicPageStart":"62","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヒトにおけるカフェイン(CAF)の代謝を定量的に把握するため、その13C標識体を用いてNMRで各代謝物の尿中排泄量を測定した。試験には1-13C-CAFと7-13C-CAFの2種類の標識体を用い、これを健康な被験者6名に服用させた後、尿中の代謝物を抽出して13C-NMR測定による一斉定量を実施した。その結果、CAFとその代謝物の13C標識メチル基のNMRシグナル位置の比較では、CAFと各代謝物が十分に分離検出されるほど異なっているため、メチル基炭素のシグナル積分値で代謝物濃度を定量できることが分かった。この13C-NMR法を用いた手法により、CAFの代謝物を分離・精製することなく、特異的に検出・定量することが可能になった。","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"五郎丸, 毅"}],"nameIdentifiers":[{"nameIdentifier":"46335","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿原, 良枝"}],"nameIdentifiers":[{"nameIdentifier":"46336","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"本屋敷, 敏雄"}],"nameIdentifiers":[{"nameIdentifier":"46337","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石津, 隆"}],"nameIdentifiers":[{"nameIdentifier":"46338","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-15"}],"displaytype":"detail","filename":"13C 標識カフェイン服用後のヒト尿中代謝物のNMR による測定.pdf","filesize":[{"value":"589.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"五郎丸毅(発表論文抄録(2010))","url":"https://fukuyama-u.repo.nii.ac.jp/record/8849/files/13C 標識カフェイン服用後のヒト尿中代謝物のNMR による測定.pdf"},"version_id":"01b72b89-1672-46b8-b696-a0a8d14f5825"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"*Caffeine(薬理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"炭素同位体(診断的利用)","subitem_subject_scheme":"Other"},{"subitem_subject":"磁気共鳴スペクトロスコピー","subitem_subject_scheme":"Other"},{"subitem_subject":"感度と特異度","subitem_subject_scheme":"Other"},{"subitem_subject":"検体取り扱い法","subitem_subject_scheme":"Other"},{"subitem_subject":"*生体内変化","subitem_subject_scheme":"Other"},{"subitem_subject":"経口投与","subitem_subject_scheme":"Other"},{"subitem_subject":"同位体標識","subitem_subject_scheme":"Other"},{"subitem_subject":"Wistarラット","subitem_subject_scheme":"Other"},{"subitem_subject":"合成化学技術","subitem_subject_scheme":"Other"},{"subitem_subject":"代謝産物(尿)","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"},{"subitem_subject":"オス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"13C標識カフェイン服用後のヒト尿中代謝物のNMRによる測定(発表論文抄録(2010))","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"13C標識カフェイン服用後のヒト尿中代謝物のNMRによる測定(発表論文抄録(2010))"},{"subitem_title":"Quantification of urinary metabolites in man after administration of 13C-labeled caffeine by NMR","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["764"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-01-15"},"publish_date":"2018-01-15","publish_status":"0","recid":"8849","relation_version_is_last":true,"title":["13C標識カフェイン服用後のヒト尿中代謝物のNMRによる測定(発表論文抄録(2010))"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:15:23.976070+00:00"}