{"created":"2023-06-19T09:51:37.326289+00:00","id":8842,"links":{},"metadata":{"_buckets":{"deposit":"e5f186d7-35ac-418d-b892-5a6bff1f5c73"},"_deposit":{"created_by":18,"id":"8842","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8842"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008842","sets":["502:503:627:764"]},"author_link":["46275","46278","45113","46167","46284","46277","45217","46273","46281","46279","46280","45218","46274","45124","45373","46283","45360","45116","45867","46282","45166","46276"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"29","bibliographicPageEnd":"52","bibliographicPageStart":"51","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effect of high and low molecular weight chitosans (HMC; 1000 kDa, LMC; 30 kDa) on oxidative stress and hypercholesterolemia was investigated using male 6-week-old Wistar Kyoto rats as a normal model (Normal-rats) and spontaneously hypertensive rat/ND mcr-cp (SHP/ND) as a metabolic syndrome model (MS-rats), respectively. In Normal-rats, the ingestion of both chitosans over a 4 week period resulted in a significant decrease in total body weight (BW), glucose (Gl), triglyceride (TG), low density lipoprotein (LDL) and serum creatinine (Cre) levels. The ingestion of both chitosans also resulted in a lowered ratio of oxidized to reduced albumin and an increase in total plasma antioxidant activity. In addition to similar results in Normal-rats, the ingestion of only HMC over a 4 week period resulted in a significant decrease in total cholesterol levels in MS-rats. Further, the ingestion of LMC resulted in a significantly higher antioxidant activity than was observed for HMC in both rat models. In in vitro studies, LMC caused a significantly higher reduction in the levels of two stable radicals, compared to HMC, and the effect was both dose- and time-dependent. The findings also show that LDL showed strong binding in the case of HMC. These results suggest that LMC has a high antioxidant activity as well as antilipidemic effects, while HMC results in a significant reduction in the levels of pro-oxidants such as LDL in the gastrointestinal tract, thereby inhibiting the subsequent development of oxidative stress in the systemic circulation in metabolic model rats.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The effect of high and low molecular weight chitosans (HMC; 1000 kDa, LMC; 30 kDa) on oxidative stress and hypercholesterolemia was investigated using male 6-week-old Wistar Kyoto rats as a normal model (Normal-rats) and spontaneously hypertensive rat/ND mcr-cp (SHP/ND) as a metabolic syndrome model (MS-rats), respectively. In Normal-rats, the ingestion of both chitosans over a 4 week period resulted in a significant decrease in total body weight (BW), glucose (Gl), triglyceride (TG), low density lipoprotein (LDL) and serum creatinine (Cre) levels. The ingestion of both chitosans also resulted in a lowered ratio of oxidized to reduced albumin and an increase in total plasma antioxidant activity. In addition to similar results in Normal-rats, the ingestion of only HMC over a 4 week period resulted in a significant decrease in total cholesterol levels in MS-rats. Further, the ingestion of LMC resulted in a significantly higher antioxidant activity than was observed for HMC in both rat models. In in vitro studies, LMC caused a significantly higher reduction in the levels of two stable radicals, compared to HMC, and the effect was both dose- and time-dependent. The findings also show that LDL showed strong binding in the case of HMC. These results suggest that LMC has a high antioxidant activity as well as antilipidemic effects, while HMC results in a significant reduction in the levels of pro-oxidants such as LDL in the gastrointestinal tract, thereby inhibiting the subsequent development of oxidative stress in the systemic circulation in metabolic model rats.","subitem_description_type":"Other"}]},"item_10002_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"46274","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Anraku, Makoto"}]},{"nameIdentifiers":[{"nameIdentifier":"46275","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Michihara, Akihiro"}]},{"nameIdentifiers":[{"nameIdentifier":"46276","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yasufuku, Taira"}]},{"nameIdentifiers":[{"nameIdentifier":"46277","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Akasaki, Kenji"}]},{"nameIdentifiers":[{"nameIdentifier":"46278","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tsuchiya, Daiju"}]},{"nameIdentifiers":[{"nameIdentifier":"46279","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nishio, Hiroaki"}]},{"nameIdentifiers":[{"nameIdentifier":"46280","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Maruyama, Toru"}]},{"nameIdentifiers":[{"nameIdentifier":"46281","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Otagiri, Masaki"}]},{"nameIdentifiers":[{"nameIdentifier":"46282","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Maezaki, Yuji"}]},{"nameIdentifiers":[{"nameIdentifier":"46283","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kondo, Yuko"}]},{"nameIdentifiers":[{"nameIdentifier":"46284","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tomida, 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