{"created":"2023-06-19T09:51:37.284438+00:00","id":8841,"links":{},"metadata":{"_buckets":{"deposit":"6b7d5281-a9d4-4194-8862-1cd8fc5f72ab"},"_deposit":{"created_by":18,"id":"8841","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8841"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008841","sets":["502:503:627:764"]},"author_link":["45166","46272","46265","46167","45236","46270","46271","46266","45879","46268","46267","45360","46269"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"29","bibliographicPageEnd":"50","bibliographicPageStart":"50","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The antioxidant properties of different low molecular weight (LMW) chitosans (CS1; 22 kDa, CS2; 38 kDa, CS3; 52 kDa, CS4; 81 kDa) were examined for possible use in extended-release tablets. The criteria used were the ability of the chitosans to reduce Cu2+, and hydroxyl and superoxide radicals and N-centered radicals derived from 1,1'-diphenyl-2-picrylhydrazyl, via the use of ESR spectrometry. CS2 showed the highest scavenging activity. CS1 and CS3, however, were much less effective and CS4 was not a viable antioxidant. The results suggest that CS2 could be useful in combating the development of oxidative stress. A series of chitosan tablets were prepared using a spray drying method and evaluated as an extended-release matrix tablet using theophylline (TPH) as a model drug. The release of TPH from the different MW chitosan tablets increased with increasing MW of the chitosan used. CS2, CS3 and CS4 showed a reasonable release activity, but CS1 showed the shortest release activity. Moreover, the CS2-TPH tablet showed the highest scavenging activity of the three chitosan tablets (CS2-CS4) using 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) radicals. These results suggest that a CS2-TPH tablet could be potentially useful in an extended-release matrix tablet with a high antioxidant activity.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The antioxidant properties of different low molecular weight (LMW) chitosans (CS1; 22 kDa, CS2; 38 kDa, CS3; 52 kDa, CS4; 81 kDa) were examined for possible use in extended-release tablets. The criteria used were the ability of the chitosans to reduce Cu2+, and hydroxyl and superoxide radicals and N-centered radicals derived from 1,1'-diphenyl-2-picrylhydrazyl, via the use of ESR spectrometry. CS2 showed the highest scavenging activity. CS1 and CS3, however, were much less effective and CS4 was not a viable antioxidant. The results suggest that CS2 could be useful in combating the development of oxidative stress. A series of chitosan tablets were prepared using a spray drying method and evaluated as an extended-release matrix tablet using theophylline (TPH) as a model drug. The release of TPH from the different MW chitosan tablets increased with increasing MW of the chitosan used. CS2, CS3 and CS4 showed a reasonable release activity, but CS1 showed the shortest release activity. Moreover, the CS2-TPH tablet showed the highest scavenging activity of the three chitosan tablets (CS2-CS4) using 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) radicals. These results suggest that a CS2-TPH tablet could be potentially useful in an extended-release matrix tablet with a high antioxidant activity.","subitem_description_type":"Other"}]},"item_10002_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"45360","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000018184429","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000018184429"}],"names":[{"name":"安福, 平"}]},{"nameIdentifiers":[{"nameIdentifier":"46167","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000016655415","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000016655415"}],"names":[{"name":"近藤, 裕子"}]},{"nameIdentifiers":[{"nameIdentifier":"45236","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014625803","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014625803"}],"names":[{"name":"秦, 季之"}]},{"nameIdentifiers":[{"nameIdentifier":"45879","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000070080215","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000070080215"}],"names":[{"name":"廣瀬, 順造"}]},{"nameIdentifiers":[{"nameIdentifier":"46272","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000019192509","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000019192509"}],"names":[{"name":"小林, 誠幸"}]},{"nameIdentifiers":[{"nameIdentifier":"45166","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005174459","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005174459"}],"names":[{"name":"冨田, 久夫"}]}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yasufuku, Taira"}],"nameIdentifiers":[{"nameIdentifier":"46265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Anraku, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"46266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kondo, Yuko"}],"nameIdentifiers":[{"nameIdentifier":"46267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hata, Toshiyuki"}],"nameIdentifiers":[{"nameIdentifier":"46268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirose, Junzo"}],"nameIdentifiers":[{"nameIdentifier":"46269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Nobuyuki"}],"nameIdentifiers":[{"nameIdentifier":"46270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomida, Hisao"}],"nameIdentifiers":[{"nameIdentifier":"46271","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-15"}],"displaytype":"detail","filename":"抗酸化作用を有する徐放性キトサン錠に関する研究.pdf","filesize":[{"value":"588.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"安福平(発表論文抄録(2010))","url":"https://fukuyama-u.repo.nii.ac.jp/record/8841/files/抗酸化作用を有する徐放性キトサン錠に関する研究.pdf"},"version_id":"12fdcb0e-bddc-4021-89e9-c174004af339"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"抗酸化作用を有する徐放性キトサン錠に関する研究(発表論文抄録(2010))","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗酸化作用を有する徐放性キトサン錠に関する研究(発表論文抄録(2010))"},{"subitem_title":"Useful Extend-release Chitosan Tablets with High Antioxidant Activity.","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["764"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-01-15"},"publish_date":"2018-01-15","publish_status":"0","recid":"8841","relation_version_is_last":true,"title":["抗酸化作用を有する徐放性キトサン錠に関する研究(発表論文抄録(2010))"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:15:38.148130+00:00"}