{"created":"2023-06-19T09:51:37.242242+00:00","id":8840,"links":{},"metadata":{"_buckets":{"deposit":"37f69818-b1ff-45e6-897f-0aab6087b7b2"},"_deposit":{"created_by":18,"id":"8840","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8840"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008840","sets":["502:503:627:764"]},"author_link":["45124","46259","45166","46258","46260","46166","46262","46263","46167","46264","46261","45360"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"29","bibliographicPageEnd":"49","bibliographicPageStart":"49","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The objective of this study was to identify polysaccharides with antioxidant properties for use as potential antioxidative compounds for extended-release matrix tablets. The antioxidant properties of five different polysaccharides, high molecular weight alginate (H-ALG), low molecular weight alginate (L-ALG), high molecular weight chitosan (H-chitosan), low molecular weight chitosan (L-chitosan), and pectic acid (PA) were examined using N-centered radicals from 1,1'-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and reducing power, based on their ability to reduce Cu(2+). L-chitosan and PA had acceptable scavenging abilities and were good radical scavengers, with good reducing power, but the H-chitosan and alginate derivatives were much less effective. The results suggest that L-chitosan and PA could be useful in combating oxidative stress. A PA and L-chitosan interpolymer complex (IPC) tablet was prepared and evaluated as an extended-release tablet matrix using theophylline (TPH) as a model drug. The release of TPH from the matrix tablet (TPH/PA/L-chitosan=200 mg:150 mg:50 mg) was slower than that from PA only (TPH/PA/chitosans=200 mg:200 mg:0 mg) or L-chitosan only (TPH/PA/L-chitosan=200 mg:0 mg:200 mg) tablet. Turbidity measurements also indicated the optimum complexation ratio for IPC between PA/L-chitosan to be 1/3, indicating an acceptable relationship between the turbidity of the complex and the release ratio of TPH. These results suggest that an L-chitosan/PA complex would be potentially useful in an extended-release IPC tablet with high antioxidant activity.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The objective of this study was to identify polysaccharides with antioxidant properties for use as potential antioxidative compounds for extended-release matrix tablets. The antioxidant properties of five different polysaccharides, high molecular weight alginate (H-ALG), low molecular weight alginate (L-ALG), high molecular weight chitosan (H-chitosan), low molecular weight chitosan (L-chitosan), and pectic acid (PA) were examined using N-centered radicals from 1,1'-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and reducing power, based on their ability to reduce Cu(2+). L-chitosan and PA had acceptable scavenging abilities and were good radical scavengers, with good reducing power, but the H-chitosan and alginate derivatives were much less effective. The results suggest that L-chitosan and PA could be useful in combating oxidative stress. A PA and L-chitosan interpolymer complex (IPC) tablet was prepared and evaluated as an extended-release tablet matrix using theophylline (TPH) as a model drug. The release of TPH from the matrix tablet (TPH/PA/L-chitosan=200 mg:150 mg:50 mg) was slower than that from PA only (TPH/PA/chitosans=200 mg:200 mg:0 mg) or L-chitosan only (TPH/PA/L-chitosan=200 mg:0 mg:200 mg) tablet. Turbidity measurements also indicated the optimum complexation ratio for IPC between PA/L-chitosan to be 1/3, indicating an acceptable relationship between the turbidity of the complex and the release ratio of TPH. These results suggest that an L-chitosan/PA complex would be potentially useful in an extended-release IPC tablet with high antioxidant activity.","subitem_description_type":"Other"}]},"item_10002_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"45166","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005174459","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005174459"}],"names":[{"name":"冨田, 久夫"}]},{"nameIdentifiers":[{"nameIdentifier":"45360","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000018184429","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000018184429"}],"names":[{"name":"安福, 平"}]},{"nameIdentifiers":[{"nameIdentifier":"46166","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005628178","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005628178"}],"names":[{"name":"藤井, 武"}]},{"nameIdentifiers":[{"nameIdentifier":"46167","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000016655415","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000016655415"}],"names":[{"name":"近藤, 裕子"}]},{"nameIdentifiers":[{"nameIdentifier":"46264","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014626001","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014626001"}],"names":[{"name":"甲斐, 俊哉"}]},{"nameIdentifiers":[{"nameIdentifier":"45124","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000003077192","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000003077192"}],"names":[{"name":"安楽, 誠"}]}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tomida, Hisao"}],"nameIdentifiers":[{"nameIdentifier":"46258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasufuku, Taira"}],"nameIdentifiers":[{"nameIdentifier":"46259","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujii, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"46260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kondo, Yuko"}],"nameIdentifiers":[{"nameIdentifier":"46261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kai, Toshiya"}],"nameIdentifiers":[{"nameIdentifier":"46262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Anraku, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"46263","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-27"}],"displaytype":"detail","filename":"抗酸化作用を有する多糖類の徐放性基材への応用.pdf","filesize":[{"value":"588.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"冨田久夫(発表論文抄録(2010))","url":"https://fukuyama-u.repo.nii.ac.jp/record/8840/files/抗酸化作用を有する多糖類の徐放性基材への応用.pdf"},"version_id":"43d5997b-4d76-46e8-9bfc-4c3674183c4c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Acridines","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Benzothiazoles","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Biphenyl Compounds","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Delayed-Action Preparations","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug Carriers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Free Radical Scavengers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nephelometry and Turbidimetry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidation-Reduction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Phenanthrolines","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Picrates","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Polysaccharides","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sulfonic Acids","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tablets","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Theophylline","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"抗酸化作用を有する多糖類の徐放性基材への応用(発表論文抄録(2010))","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗酸化作用を有する多糖類の徐放性基材への応用(発表論文抄録(2010))"},{"subitem_title":"Polysaccharides as potential antioxidative compounds for extended-release matrix tablets.","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["764"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-27"},"publish_date":"2017-12-27","publish_status":"0","recid":"8840","relation_version_is_last":true,"title":["抗酸化作用を有する多糖類の徐放性基材への応用(発表論文抄録(2010))"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:15:39.767793+00:00"}