{"created":"2023-06-19T09:51:37.076035+00:00","id":8836,"links":{},"metadata":{"_buckets":{"deposit":"018d2017-d641-4e28-a30d-9c6614862e88"},"_deposit":{"created_by":18,"id":"8836","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8836"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008836","sets":["502:503:627:764"]},"author_link":["45116","45113","46243","46239","46241","46238","46242","46240"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"29","bibliographicPageEnd":"44","bibliographicPageStart":"44","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"σ-tocotrienolの引き起こす副作用(細胞からのリソソーム放出と細胞のcholesterol含有量減少)について検討した。また、メラノソーム(リソソームに関連した細胞小器官)の放出についても調べた。β-glucuronidase(メラノソームおよびリソソーム酵素)活性、melanin含有量(メラノソームマーカー)、tyrosinase(メラノソーム酵素)活性は、細胞培養培地において増加しなかったため、リソソーム、メラノソームのどちらも、σ-tocotrienolで処理した細胞からは放出されなかった。Mevalonate pyrophosphate decarboxylase(MPD、cholesterolの合成酵素)は、σ-tocotrienolで処理した細胞において有意に減少したが、cholesterol含有量は減少しなかった。σ-tocotrienolはMPDを引き起こすが、σ-tocotrienolは色素過剰の治療薬または予防薬として、また重症の副作用(cholesterol含有量の減少とリソソーム/メラノソームの放出)を引き起こさないホワイトニングおよび/または美白化粧品の成分として有用となる可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"σ-tocotrienolの引き起こす副作用(細胞からのリソソーム放出と細胞のcholesterol含有量減少)について検討した。また、メラノソーム(リソソームに関連した細胞小器官)の放出についても調べた。β-glucuronidase(メラノソームおよびリソソーム酵素)活性、melanin含有量(メラノソームマーカー)、tyrosinase(メラノソーム酵素)活性は、細胞培養培地において増加しなかったため、リソソーム、メラノソームのどちらも、σ-tocotrienolで処理した細胞からは放出されなかった。Mevalonate pyrophosphate decarboxylase(MPD、cholesterolの合成酵素)は、σ-tocotrienolで処理した細胞において有意に減少したが、cholesterol含有量は減少しなかった。σ-tocotrienolはMPDを引き起こすが、σ-tocotrienolは色素過剰の治療薬または予防薬として、また重症の副作用(cholesterol含有量の減少とリソソーム/メラノソームの放出)を引き起こさないホワイトニングおよび/または美白化粧品の成分として有用となる可能性が示唆された。","subitem_description_type":"Other"}]},"item_10002_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"45113","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014625611","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014625611"}],"names":[{"name":"道原, 明宏"}]},{"nameIdentifiers":[{"nameIdentifier":"46238","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000342904992","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000342904992"}],"names":[{"name":"縞谷, 舞"}]},{"nameIdentifiers":[{"nameIdentifier":"46243","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000342904976","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000342904976"}],"names":[{"name":"森田, 祥代"}]},{"nameIdentifiers":[{"nameIdentifier":"45116","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005185543","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005185543"}],"names":[{"name":"赤崎, 健司"}]}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Akihiro, Michihara"}],"nameIdentifiers":[{"nameIdentifier":"46239","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mai, Shimatani"}],"nameIdentifiers":[{"nameIdentifier":"46240","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sachiyo, Morita"}],"nameIdentifiers":[{"nameIdentifier":"46241","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kenji, Akasaki"}],"nameIdentifiers":[{"nameIdentifier":"46242","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-27"}],"displaytype":"detail","filename":"デルタ‐トコトリエノールで処理したマウスメラノーマ細胞中のメバロン酸二リン酸脱炭酸酵素の減少はリソソームやメラノソームの放出とコレステロール含量の低下に関与していない.pdf","filesize":[{"value":"614.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"道原明宏(発表論文抄録(2010))","url":"https://fukuyama-u.repo.nii.ac.jp/record/8836/files/デルタ‐トコトリエノールで処理したマウスメラノーマ細胞中のメバロン酸二リン酸脱炭酸酵素の減少はリソソームやメラノソームの放出とコレステロール含量の低下に関与していない.pdf"},"version_id":"8356e7a7-9e66-4394-8db9-c704408c424d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"*Carboxy-Lyases","subitem_subject_scheme":"Other"},{"subitem_subject":"*Cholesterol","subitem_subject_scheme":"Other"},{"subitem_subject":"リソソーム","subitem_subject_scheme":"Other"},{"subitem_subject":"Melanins","subitem_subject_scheme":"Other"},{"subitem_subject":"*黒色腫(実験的)","subitem_subject_scheme":"Other"},{"subitem_subject":"ポリアクリルアミドゲル電気泳動","subitem_subject_scheme":"Other"},{"subitem_subject":"ウエスタンブロッティング","subitem_subject_scheme":"Other"},{"subitem_subject":"Monophenol Monooxygenase","subitem_subject_scheme":"Other"},{"subitem_subject":"メラノソーム","subitem_subject_scheme":"Other"},{"subitem_subject":"*Tocotrienols(薬理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"*腫瘍細胞系","subitem_subject_scheme":"Other"},{"subitem_subject":"*Diphosphomevalonate Decarboxylase","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"},{"subitem_subject":"*Carboxy-Lyases","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"*Cholesterol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Melanins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Monophenol Monooxygenase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"*Tocotrienols","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"*Diphosphomevalonate Decarboxylase","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"デルタ‐トコトリエノールで処理したマウスメラノーマ細胞中のメバロン酸二リン酸脱炭酸酵素の減少はリソソームやメラノソームの放出とコレステロール含量の低下に関与していない(発表論文抄録(2010))","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"デルタ‐トコトリエノールで処理したマウスメラノーマ細胞中のメバロン酸二リン酸脱炭酸酵素の減少はリソソームやメラノソームの放出とコレステロール含量の低下に関与していない(発表論文抄録(2010))"},{"subitem_title":"Reduction of Mevalonate Pyrophosphate Decarboxylase in Mouse Melanoma Cells Treated with δ-Toeotrienol Is Not Associated with Reduction of Cholesterol Content or Release of Lysosomes and Melanosomes","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["764"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-27"},"publish_date":"2017-12-27","publish_status":"0","recid":"8836","relation_version_is_last":true,"title":["デルタ‐トコトリエノールで処理したマウスメラノーマ細胞中のメバロン酸二リン酸脱炭酸酵素の減少はリソソームやメラノソームの放出とコレステロール含量の低下に関与していない(発表論文抄録(2010))"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:15:46.552675+00:00"}