{"created":"2023-06-19T09:51:36.992675+00:00","id":8834,"links":{},"metadata":{"_buckets":{"deposit":"153e8f0a-9d09-426b-9c2c-a7efd97cdda4"},"_deposit":{"created_by":18,"id":"8834","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8834"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008834","sets":["502:503:627:764"]},"author_link":["45184","46232","45181","46231"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"29","bibliographicPageEnd":"42","bibliographicPageStart":"42","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Since the role of endothelin (ET)-1 in lipoprotein metabolism in tumor cells is unclear, we investigated the effect of ET-1 on the secretion of lipoprotein lipase (LPL) from mouse Ehrlich ascites tumor cells. ET-1 increased the secretion of LPL from these cells in a time-dependent manner. Two antagonists of ET-receptor type A (ET-A), namely, BQ123 and FR139317, inhibited the stimulatory effect of ET-1 on the secretion of LPL. However, an antagonist of ET-receptor type B (ET-B), BQ788, did not have any effect. Neomycin, a phospholipase C (PLC) inhibitor, and H-7, a protein kinase C (PKC) inhibitor, also suppressed the ET-1-stimulated secretion of LPL. ET-1 also increased PKC activity in tumor cells in a dose-dependent manner. These results imply that ET-1 stimulates secretion of LPL from tumor cells by stimulating the PLC-PKC signaling pathway through the ET-A receptor rather than the ET-B receptor.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Since the role of endothelin (ET)-1 in lipoprotein metabolism in tumor cells is unclear, we investigated the effect of ET-1 on the secretion of lipoprotein lipase (LPL) from mouse Ehrlich ascites tumor cells. ET-1 increased the secretion of LPL from these cells in a time-dependent manner. Two antagonists of ET-receptor type A (ET-A), namely, BQ123 and FR139317, inhibited the stimulatory effect of ET-1 on the secretion of LPL. However, an antagonist of ET-receptor type B (ET-B), BQ788, did not have any effect. Neomycin, a phospholipase C (PLC) inhibitor, and H-7, a protein kinase C (PKC) inhibitor, also suppressed the ET-1-stimulated secretion of LPL. ET-1 also increased PKC activity in tumor cells in a dose-dependent manner. These results imply that ET-1 stimulates secretion of LPL from tumor cells by stimulating the PLC-PKC signaling pathway through the ET-A receptor rather than the ET-B receptor.","subitem_description_type":"Other"}]},"item_10002_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"45184","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014625914","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014625914"}],"names":[{"name":"螻川内, 理恵"}]},{"nameIdentifiers":[{"nameIdentifier":"45181","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005151603","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005151603"}],"names":[{"name":"森田, 哲生"}]}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kerakawati, Rie"}],"nameIdentifiers":[{"nameIdentifier":"46231","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morita, Tetsuo"}],"nameIdentifiers":[{"nameIdentifier":"46232","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-27"}],"displaytype":"detail","filename":"エンドセリン-1 によるエールリッヒ腹水癌細胞からのリポタンパク質リパーゼの分泌.pdf","filesize":[{"value":"588.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"螻川内理恵(発表論文抄録(2010))","url":"https://fukuyama-u.repo.nii.ac.jp/record/8834/files/エンドセリン-1 によるエールリッヒ腹水癌細胞からのリポタンパク質リパーゼの分泌.pdf"},"version_id":"59ff1e4d-c5c3-4974-b9fc-e3d351f048a1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"lipoprotein lipase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelin-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelin receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ehrlich ascites tumor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"エンドセリン-1 によるエールリッヒ腹水癌細胞からのリポタンパク質リパーゼの分泌(発表論文抄録(2010))","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"エンドセリン-1 によるエールリッヒ腹水癌細胞からのリポタンパク質リパーゼの分泌(発表論文抄録(2010))"},{"subitem_title":"Endothelin-1 Stimulates Secretion of Lipoprotein Lipase from Ehrlich Ascites Tumor Cells","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["764"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-27"},"publish_date":"2017-12-27","publish_status":"0","recid":"8834","relation_version_is_last":true,"title":["エンドセリン-1 によるエールリッヒ腹水癌細胞からのリポタンパク質リパーゼの分泌(発表論文抄録(2010))"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:15:49.619413+00:00"}