{"created":"2023-06-19T09:51:36.445018+00:00","id":8820,"links":{},"metadata":{"_buckets":{"deposit":"2824db23-ad4e-47fb-804b-62cbe9cd5433"},"_deposit":{"created_by":18,"id":"8820","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8820"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008820","sets":["502:503:627:779"]},"author_link":["45116","45124","46162","45166","46161","45113","46159","46163","46158","46156","46155","46160","46157","46164"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"30","bibliographicPageEnd":"16","bibliographicPageStart":"16","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The spontaneously hypertensive rat (SHR)/NDmcr-cp (SHR-cp), which is a metabolic syndrome model rat, was reported to show hypercholesteremia, as compared with lean littermates. The serum total cholesterol level in SHR-cp at 18 weeks of age is higher than that of normotensive Wistar Kyoto rat (WKY), but that in SHR-cp at 10 weeks of age is the same. The objective of this study is to clarify whether there are differences in the system regulating serum cholesterol levels between SHR-cp and WKY at 10 weeks of age. Total serum cholesterol levels, and cholesterol levels of high density lipoprotein (HDL), low density lipoprotein (LDL), and very low density lipoprotein (VLDL) were similar in the two strains. However, the cholesterol levels in the liver of SHR-cp were lower than those of WKY. Next, mRNA levels of receptors (scavenger receptor class B type 1 [SRB1], LDL receptor [LDLR]) involved in uptake from serum to liver or enzymes of cholesterol catabolism (CYP7A1 and CYP8B1) and biosynthesis (mevalonate pyrophosphate decarboxylases [MPD]) in liver were compared between SHR-cp and WKY. High levels of MPD and LDLR and low levels of SRB1 were shown in SHR-cp, as compared with WKY. CYP7A1 and CYP8B1 levels were similar between SHR-cp and WKY. These results suggest that the serum cholesterol level in SHR-cp by the balance or regulation between the rise in cholesterol uptake and reduction in cholesterol biosynthesis in the liver is the same as that in WKY.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The spontaneously hypertensive rat (SHR)/NDmcr-cp (SHR-cp), which is a metabolic syndrome model rat, was reported to show hypercholesteremia, as compared with lean littermates. The serum total cholesterol level in SHR-cp at 18 weeks of age is higher than that of normotensive Wistar Kyoto rat (WKY), but that in SHR-cp at 10 weeks of age is the same. The objective of this study is to clarify whether there are differences in the system regulating serum cholesterol levels between SHR-cp and WKY at 10 weeks of age. Total serum cholesterol levels, and cholesterol levels of high density lipoprotein (HDL), low density lipoprotein (LDL), and very low density lipoprotein (VLDL) were similar in the two strains. However, the cholesterol levels in the liver of SHR-cp were lower than those of WKY. Next, mRNA levels of receptors (scavenger receptor class B type 1 [SRB1], LDL receptor [LDLR]) involved in uptake from serum to liver or enzymes of cholesterol catabolism (CYP7A1 and CYP8B1) and biosynthesis (mevalonate pyrophosphate decarboxylases [MPD]) in liver were compared between SHR-cp and WKY. High levels of MPD and LDLR and low levels of SRB1 were shown in SHR-cp, as compared with WKY. CYP7A1 and CYP8B1 levels were similar between SHR-cp and WKY. These results suggest that the serum cholesterol level in SHR-cp by the balance or regulation between the rise in cholesterol uptake and reduction in cholesterol biosynthesis in the liver is the same as that in WKY.","subitem_description_type":"Other"}]},"item_10002_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"46158","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Michihara, Akihiro"}]},{"nameIdentifiers":[{"nameIdentifier":"46159","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Anraku, Makoto"}]},{"nameIdentifiers":[{"nameIdentifier":"46160","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000020088549","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000020088549"}],"names":[{"name":"Abe, Aoi"}]},{"nameIdentifiers":[{"nameIdentifier":"46161","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000020088566","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000020088566"}],"names":[{"name":"Kinoshita, Haruko"}]},{"nameIdentifiers":[{"nameIdentifier":"46162","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000020088578","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000020088578"}],"names":[{"name":"Kamizaki, Yohei"}]},{"nameIdentifiers":[{"nameIdentifier":"46163","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tomida, Hisao"}]},{"nameIdentifiers":[{"nameIdentifier":"46164","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Akasaki, Kenji"}]}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"道原, 明宏"}],"nameIdentifiers":[{"nameIdentifier":"45113","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014625611","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014625611"}]},{"creatorNames":[{"creatorName":"安楽, 誠"}],"nameIdentifiers":[{"nameIdentifier":"45124","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000003077192","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000003077192"}]},{"creatorNames":[{"creatorName":"阿部, 葵"}],"nameIdentifiers":[{"nameIdentifier":"46155","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木下, 玄子"}],"nameIdentifiers":[{"nameIdentifier":"46156","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"神崎, 洋平"}],"nameIdentifiers":[{"nameIdentifier":"46157","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"冨田, 久夫"}],"nameIdentifiers":[{"nameIdentifier":"45166","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005174459","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005174459"}]},{"creatorNames":[{"creatorName":"赤崎, 健司"}],"nameIdentifiers":[{"nameIdentifier":"45116","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005185543","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005185543"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-25"}],"displaytype":"detail","filename":"30-16.pdf","filesize":[{"value":"83.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"道原明宏(発表論文抄録(2011))","url":"https://fukuyama-u.repo.nii.ac.jp/record/8820/files/30-16.pdf"},"version_id":"8cfb3286-c4dd-48eb-95c5-3694192fc7e2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"metabolic syndrome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cholesterol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mevalonate pyrophosphate decarboxylase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Wistar Kyoto rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SHR/NDmcr-cp","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"10週齢のメタボリックラットと対照ラット間の肝臓におけるコレステロール調節酵素とレセプターの比較(発表論文抄録(2011))","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"10週齢のメタボリックラットと対照ラット間の肝臓におけるコレステロール調節酵素とレセプターの比較(発表論文抄録(2011))"},{"subitem_title":"Comparison of Receptors and Enzymes Regulating Cholesterol Levels in Liver between SHR/NDmcr-cp Rats and Normotensive Wistar Kyoto Rats at Ten Weeks of Age","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-25"},"publish_date":"2017-12-25","publish_status":"0","recid":"8820","relation_version_is_last":true,"title":["10週齢のメタボリックラットと対照ラット間の肝臓におけるコレステロール調節酵素とレセプターの比較(発表論文抄録(2011))"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:16:10.953539+00:00"}