{"created":"2023-06-19T09:51:36.317178+00:00","id":8817,"links":{},"metadata":{"_buckets":{"deposit":"f0c4059d-8bfb-4c8e-a026-ef29765efee6"},"_deposit":{"created_by":18,"id":"8817","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8817"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008817","sets":["502:503:627:779"]},"author_link":["46133","45640","45101","46136","46135","46132","46134","45722"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"30","bibliographicPageEnd":"13","bibliographicPageStart":"12","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Daiokanzoto (DKT), a Kampo medicine that includes the combination of two crude drugs (rhubarb and glycyrrhiza), is clinically effective for constipation. The aim of this study is to clarify the influence of glycyrrhiza, three glycyrrhiza constituents (glycyrrhizin, liquiritin, and liquiritin apioside), and eight antibiotics on the purgative action of DKT, rhubarb, or sennoside A, a constituent of rhubarb, in mice. The purgative actions of rhubarb and sennoside A were significantly intensified when glycyrrhiza was co-administered orally to mice. Liquiritin and liquiritin apioside but not glycyrrhizin showed significant amplification of the purgative action in a dose-dependent manner. The purgative actions of DKT and sennoside A were significantly reduced by the pre-administration of ampicillin, cefcapene pivoxil, faropenem, fosfomycin, or kanamycin, but were not affected by the pre-administration of clarithromycin or levofloxacin. On the other hand, the purgative action of sennoside A was significantly reduced by the pre-administration of minocycline, whereas that of DKT was not affected. The effect of minocycline on the purgative action of sennoside A was lost when glycyrrhiza was co-administered. These results suggest that liquiritin and liquiritin apioside contribute as active substances for the purgative action of DKT, and some antibiotics reduce the purgative action of DKT and sennoside A. Furthermore, glycyrrhiza has the ability to recover the purgative action of sennoside A suppressed by minocycline via an unknown mechanism.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Daiokanzoto (DKT), a Kampo medicine that includes the combination of two crude drugs (rhubarb and glycyrrhiza), is clinically effective for constipation. The aim of this study is to clarify the influence of glycyrrhiza, three glycyrrhiza constituents (glycyrrhizin, liquiritin, and liquiritin apioside), and eight antibiotics on the purgative action of DKT, rhubarb, or sennoside A, a constituent of rhubarb, in mice. The purgative actions of rhubarb and sennoside A were significantly intensified when glycyrrhiza was co-administered orally to mice. Liquiritin and liquiritin apioside but not glycyrrhizin showed significant amplification of the purgative action in a dose-dependent manner. The purgative actions of DKT and sennoside A were significantly reduced by the pre-administration of ampicillin, cefcapene pivoxil, faropenem, fosfomycin, or kanamycin, but were not affected by the pre-administration of clarithromycin or levofloxacin. On the other hand, the purgative action of sennoside A was significantly reduced by the pre-administration of minocycline, whereas that of DKT was not affected. The effect of minocycline on the purgative action of sennoside A was lost when glycyrrhiza was co-administered. These results suggest that liquiritin and liquiritin apioside contribute as active substances for the purgative action of DKT, and some antibiotics reduce the purgative action of DKT and sennoside A. Furthermore, glycyrrhiza has the ability to recover the purgative action of sennoside A suppressed by minocycline via an unknown mechanism.","subitem_description_type":"Other"}]},"item_10002_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"46132","nameIdentifierScheme":"WEKO"}],"names":[{"name":"松井, 絵未"}]},{"nameIdentifiers":[{"nameIdentifier":"45640","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000017047048","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000017047048"}],"names":[{"name":"高山, 健人"}]},{"nameIdentifiers":[{"nameIdentifier":"45722","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002747434","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002747434"}],"names":[{"name":"佐藤, 英治"}]},{"nameIdentifiers":[{"nameIdentifier":"45101","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000060169141","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000060169141"}],"names":[{"name":"岡村, 信幸"}]}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsui, Emi"}],"nameIdentifiers":[{"nameIdentifier":"46133","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takayama, Kento"}],"nameIdentifiers":[{"nameIdentifier":"46134","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Eiji"}],"nameIdentifiers":[{"nameIdentifier":"46135","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okamura, Nobuyuki"}],"nameIdentifiers":[{"nameIdentifier":"46136","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-22"}],"displaytype":"detail","filename":"30-12.pdf","filesize":[{"value":"80.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"松井絵未(発表論文抄録(2011))","url":"https://fukuyama-u.repo.nii.ac.jp/record/8817/files/30-12.pdf"},"version_id":"96237651-6c6a-4dd4-b25f-fdda7ceed549"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anthraquinones","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anti-Bacterial Agents","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Glycyrrhiza","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Laxatives","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Medicine, Kampo","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Plant Extracts","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Senna Extract","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"センノシドAの下剤活性に対する甘草ならびに抗生物質の影響(発表論文抄録(2011))","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"センノシドAの下剤活性に対する甘草ならびに抗生物質の影響(発表論文抄録(2011))"},{"subitem_title":"The influence of glycyrrhiza and antibiotics on the purgative action of sennoside A from Daiokanzoto in mice.","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-22"},"publish_date":"2017-12-22","publish_status":"0","recid":"8817","relation_version_is_last":true,"title":["センノシドAの下剤活性に対する甘草ならびに抗生物質の影響(発表論文抄録(2011))"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:16:15.528730+00:00"}