{"created":"2023-06-19T09:51:34.009637+00:00","id":8766,"links":{},"metadata":{"_buckets":{"deposit":"9e436528-2e78-433c-b25e-068d5414eee2"},"_deposit":{"created_by":18,"id":"8766","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8766"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008766","sets":["502:503:627:783"]},"author_link":["45640","45827","45826","45110","45101","45308","45828","45825"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"31","bibliographicPageEnd":"29","bibliographicPageStart":"28","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Rhubarb is one of the most well-known herbal medicines that constitute daiokanzoto (DKT), which is clinically effective for constipation. Sennoside A is transformed into an active metabolite, rheinanthrone, by intestinal bacteria. Sennoside A in rhubarb showed significantly accelerated metabolic activity in intestinal bacteria in comparison with sennoside A alone. In this study, we investigated the influence of rhubarb constituents on the metabolism and purgative activity of sennoside A. The 20% MeOH-eluted fraction separated by MCI-gel CHP-20P column chromatography from the water extract of rhubarb showed sennoside A metabolic activity similar to that of rhubarb extract. The 20% MeOH elute was further purified and rhein 8-O-β-D-glucopyranoside (RG) was isolated. The metabolic activity of sennoside A was significantly accelerated by increasing the level of RG. Moreover, rhein, emodin and aloe-emodin also accelerated sennoside A metabolism. The purgative activity of sennoside A was significantly accelerated when RG or rhein was concomitantly given with sennoside A in a dose-dependent manner. These results suggest that anthraquinones contribute to the purgative action of sennoside A in rhubarb. Therefore, it is assumed that the influence of anthraquinones on the fate of rheinanthrone transformed from sennoside A may promote the purgative action of sennoside A.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Rhubarb is one of the most well-known herbal medicines that constitute daiokanzoto (DKT), which is clinically effective for constipation. Sennoside A is transformed into an active metabolite, rheinanthrone, by intestinal bacteria. Sennoside A in rhubarb showed significantly accelerated metabolic activity in intestinal bacteria in comparison with sennoside A alone. In this study, we investigated the influence of rhubarb constituents on the metabolism and purgative activity of sennoside A. The 20% MeOH-eluted fraction separated by MCI-gel CHP-20P column chromatography from the water extract of rhubarb showed sennoside A metabolic activity similar to that of rhubarb extract. The 20% MeOH elute was further purified and rhein 8-O-β-D-glucopyranoside (RG) was isolated. The metabolic activity of sennoside A was significantly accelerated by increasing the level of RG. Moreover, rhein, emodin and aloe-emodin also accelerated sennoside A metabolism. The purgative activity of sennoside A was significantly accelerated when RG or rhein was concomitantly given with sennoside A in a dose-dependent manner. These results suggest that anthraquinones contribute to the purgative action of sennoside A in rhubarb. Therefore, it is assumed that the influence of anthraquinones on the fate of rheinanthrone transformed from sennoside A may promote the purgative action of sennoside A.","subitem_description_type":"Other"}]},"item_10002_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"45640","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000017047048","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000017047048"}],"names":[{"name":"高山, 健人"}]},{"nameIdentifiers":[{"nameIdentifier":"45308","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000243751410","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000243751410"}],"names":[{"name":"堤, 広之"}]},{"nameIdentifiers":[{"nameIdentifier":"45110","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005188259","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005188259"}],"names":[{"name":"石津, 隆"}]},{"nameIdentifiers":[{"nameIdentifier":"45101","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000060169141","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000060169141"}],"names":[{"name":"岡村, 信幸"}]}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takayama, Kento"}],"nameIdentifiers":[{"nameIdentifier":"45825","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsutsumi, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"45826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishizu, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"45827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okamura, Nobuyuki"}],"nameIdentifiers":[{"nameIdentifier":"45828","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-20"}],"displaytype":"detail","filename":"31-28.pdf","filesize":[{"value":"175.7 kB"}],"format":"application/pdf","license_note":"Copyright (c) 2013 by Fukuyama University","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"高山健人(発表論文抄録(2012))","url":"https://fukuyama-u.repo.nii.ac.jp/record/8766/files/31-28.pdf"},"version_id":"7877a217-2978-438d-9873-8b8122ccbb63"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anthracenes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anthraquinones","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bacteria","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cathartics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Constipation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dose-Response Relationship, Drug","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug Synergism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drugs, Chinese Herbal","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Emodin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Intestines","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mice, Inbred Strains","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Monosaccharides","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Phytotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rheum","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Senna Extract","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"大黄のセンノシドA下剤活性に対するレイン8-O-β-D-グルコピラノサイドの影響(発表論文抄録(2012))","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大黄のセンノシドA下剤活性に対するレイン8-O-β-D-グルコピラノサイドの影響(発表論文抄録(2012))"},{"subitem_title":"The influence of rhein 8-O-β-D-glucopyranoside on the purgative action of sennoside A from rhubarb in mice.","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["783"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-20"},"publish_date":"2017-12-20","publish_status":"0","recid":"8766","relation_version_is_last":true,"title":["大黄のセンノシドA下剤活性に対するレイン8-O-β-D-グルコピラノサイドの影響(発表論文抄録(2012))"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:17:23.872918+00:00"}