@article{oai:fukuyama-u.repo.nii.ac.jp:00008760, author = {Matsumoto, Kohji and Choshi, Tominari and Hourai, Mai and Zamami, Yoshito and Sasaki, Kenji and Abe, Takumi and Ishikura, Minoru and Hatae, Noriyuki and Iwamura, Tatsunori and Tohyama, Shigeo and Nobuhiro, Junko and Hibino, Satoshi}, issue = {31}, journal = {福山大学薬学部研究年報, Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University}, month = {Dec}, note = {We synthesized calothrixin B using our developed biomimetic method and derived N-alkyl-calothrixins A and B. The in vitro antimalarial activity of the calothrixin derivatives, including calothrixins A and B, against the Plasmodium falciparum FCR-3 strain was evaluated. All test compounds exhibited antimalarial activity over a concentration range of 6.4×10(-6)-1.2×10(-7) M., We synthesized calothrixin B using our developed biomimetic method and derived N-alkyl-calothrixins A and B. The in vitro antimalarial activity of the calothrixin derivatives, including calothrixins A and B, against the Plasmodium falciparum FCR-3 strain was evaluated. All test compounds exhibited antimalarial activity over a concentration range of 6.4×10(-6)-1.2×10(-7) M.}, pages = {22--22}, title = {Calothrixins A、BとそのN-アルキル置換誘導体の合成と抗マラリア活性(発表論文抄録(2012))}, year = {2013} }