{"created":"2023-06-19T09:51:32.890582+00:00","id":8740,"links":{},"metadata":{"_buckets":{"deposit":"7fa2de4a-a340-48af-b2f0-af2855ca9e50"},"_deposit":{"created_by":18,"id":"8740","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8740"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008740","sets":["502:503:627:782"]},"author_link":["45338","45658","45661","45669","45674","45663","45672","45108","45652","45653","45651","45667","45662","45664","45656","45665","45668","45660","45673","45666","45670","45337","45657","45671","45655","45654","45659","45106"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"32","bibliographicPageEnd":"30","bibliographicPageStart":"29","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The therapeutic drug monitoring of paroxetine could be used to optimize the pharmacological treatment of depressed patients. A simple and sensitive high-performance liquid chromatography procedure was developed for the determination of paroxetine in serum. After simple pretreatment of serum (50 μL) with acetonitrile and o-phthalaldehyde, paroxetine was derivatized with 4-(5,6-dimethoxy-2-phthalimidinyl)-2-methoxyphenylsulfonyl chloride at 70°C for 20 min in borate buffer (0.1 mol/L, pH 8.0) to produce a fluorescent product. The derivative was separated on a reversed-phase column at 40°C for stepwise elution with (A) acetic acid (10 mmol/L) and (B) acetonitrile. The flow rate was 1.0 mL/min. The fluorescence intensity was monitored at excitation and emission wavelengths of 320 and 400 nm, respectively. The within-day and day-to-day relative standard deviations were 3.0-3.4 and 2.7-8.3%, respectively. The detection limit of paroxetine was 8.3 fmol at a signal-to-noise ratio of 3. As the proposed method that only requires a small quantity of serum (50 μL) is simple, sensitive and reproducible, it would be useful for clinical and biochemical research as well as drug monitoring.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The therapeutic drug monitoring of paroxetine could be used to optimize the pharmacological treatment of depressed patients. A simple and sensitive high-performance liquid chromatography procedure was developed for the determination of paroxetine in serum. After simple pretreatment of serum (50 μL) with acetonitrile and o-phthalaldehyde, paroxetine was derivatized with 4-(5,6-dimethoxy-2-phthalimidinyl)-2-methoxyphenylsulfonyl chloride at 70°C for 20 min in borate buffer (0.1 mol/L, pH 8.0) to produce a fluorescent product. The derivative was separated on a reversed-phase column at 40°C for stepwise elution with (A) acetic acid (10 mmol/L) and (B) acetonitrile. The flow rate was 1.0 mL/min. The fluorescence intensity was monitored at excitation and emission wavelengths of 320 and 400 nm, respectively. The within-day and day-to-day relative standard deviations were 3.0-3.4 and 2.7-8.3%, respectively. The detection limit of paroxetine was 8.3 fmol at a signal-to-noise ratio of 3. As the proposed method that only requires a small quantity of serum (50 μL) is simple, sensitive and reproducible, it would be useful for clinical and biochemical research as well as drug monitoring.","subitem_description_type":"Other"}]},"item_10002_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"45108","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006296797","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006296797"}],"names":[{"name":"井上, 裕文"}]},{"nameIdentifiers":[{"nameIdentifier":"45665","nameIdentifierScheme":"WEKO"}],"names":[{"name":"原田, 卓也"}]},{"nameIdentifiers":[{"nameIdentifier":"45338","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002858230","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002858230"}],"names":[{"name":"江藤, 精二"}]},{"nameIdentifiers":[{"nameIdentifier":"45666","nameIdentifierScheme":"WEKO"}],"names":[{"name":"中嶋, 研"}]},{"nameIdentifiers":[{"nameIdentifier":"45667","nameIdentifierScheme":"WEKO"}],"names":[{"name":"指宿, 卓也"}]},{"nameIdentifiers":[{"nameIdentifier":"45668","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000342904965","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000342904965"}],"names":[{"name":"古謝, 景子"}]},{"nameIdentifiers":[{"nameIdentifier":"45337","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005189599","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005189599"}],"names":[{"name":"伊達, 有子"}]},{"nameIdentifiers":[{"nameIdentifier":"45669","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000279907278","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000279907278"}],"names":[{"name":"實松, 絵美子"}]},{"nameIdentifiers":[{"nameIdentifier":"45670","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002858586","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002858586"}],"names":[{"name":"篠原, 義剛"}]},{"nameIdentifiers":[{"nameIdentifier":"45671","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002858591","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002858591"}],"names":[{"name":"高橋, 浩二郎"}]},{"nameIdentifiers":[{"nameIdentifier":"45672","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090248568","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000090248568"}],"names":[{"name":"吉村, 玲児"}]},{"nameIdentifiers":[{"nameIdentifier":"45673","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000030130876","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000030130876"}],"names":[{"name":"中村, 純"}]},{"nameIdentifiers":[{"nameIdentifier":"45674","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000345371922","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000345371922"}],"names":[{"name":"小嶋, 英二朗"}]},{"nameIdentifiers":[{"nameIdentifier":"45106","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005174471","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005174471"}],"names":[{"name":"鶴田, 泰人"}]}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Inoue, Hirofumi"}],"nameIdentifiers":[{"nameIdentifier":"45651","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Harada, Takuya"}],"nameIdentifiers":[{"nameIdentifier":"45652","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Eto, Seiji"}],"nameIdentifiers":[{"nameIdentifier":"45653","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakashima, Ken"}],"nameIdentifiers":[{"nameIdentifier":"45654","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ibusuki, Takuya"}],"nameIdentifiers":[{"nameIdentifier":"45655","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kosha, Keiko"}],"nameIdentifiers":[{"nameIdentifier":"45656","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Date, Yuuko"}],"nameIdentifiers":[{"nameIdentifier":"45657","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sanematsu, Emiko"}],"nameIdentifiers":[{"nameIdentifier":"45658","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinohara, Yoshitake"}],"nameIdentifiers":[{"nameIdentifier":"45659","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Kojiro"}],"nameIdentifiers":[{"nameIdentifier":"45660","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshimura, Reiji"}],"nameIdentifiers":[{"nameIdentifier":"45661","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Jun"}],"nameIdentifiers":[{"nameIdentifier":"45662","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kojima, Eijiro"}],"nameIdentifiers":[{"nameIdentifier":"45663","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuruta, Yasuto"}],"nameIdentifiers":[{"nameIdentifier":"45664","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-19"}],"displaytype":"detail","filename":"32-29.pdf","filesize":[{"value":"194.2 kB"}],"format":"application/pdf","license_note":"Copyright (c) 2014 by Fukuyama University","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"井上裕文(発表論文抄録(2013))","url":"https://fukuyama-u.repo.nii.ac.jp/record/8740/files/32-29.pdf"},"version_id":"b0fe7ae8-ff68-4621-9196-f9403a4c9a3f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adult","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chromatography, High Pressure Liquid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Female","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fluorescent Dyes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Limit of Detection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Middle Aged","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Paroxetine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Phthalimides","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Reproducibility of Results","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin 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