{"created":"2023-06-19T09:51:32.674679+00:00","id":8735,"links":{},"metadata":{"_buckets":{"deposit":"5875f8f7-216b-438d-81f7-d846bc7b1329"},"_deposit":{"created_by":18,"id":"8735","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8735"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008735","sets":["502:503:627:782"]},"author_link":["45632","45633","45628","45629","45634","45631","45636","45635","45624","45625","45630","45626","45627","45637"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"32","bibliographicPageEnd":"22","bibliographicPageStart":"22","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"  Enalaprilat (H<sub>2</sub>L), which is the active metabolite of the pro-drug enalapril, is an angiotensin-converting enzyme inhibitor. Some side effects such as neurodegeneration and taste disorder can be related to copper or zinc deficiency, which would be caused by the metal complex formation of dianionic elalaprilat (L<sup>2−</sup>). For a better understanding of this phenomenon, we investigated the solution species of enalaprilat in the presence of copper(II) or zinc(II) ions by pH titration analysis with <i>I</i>=0.10 <small>M</small> (NaCl) at 25℃. The 1:1 complex formation constants (<i>K</i><sub>ML</sub>=[ML]/[M<sup>2+</sup>][L<sup>2−</sup>] <small>M</small><sup>−1</sup>) of 10<sup>7.4</sup> for CuL and 10<sup>4.4</sup> for ZnL complexes were evaluated, indicating the presence of those complexes at a physiological pH. Furthermore, partition experiments with a two-phase system of 1-butanol/water at 25℃ disclosed that copper(II) and zinc(II) complexes of enalaprilat were partially extracted into the organic layer. In the absence of those metal ions, enalaprilat was not soluble in the 1-butanol phase. The increase in lipophilicity of enalaprilat by metal complexation suggests that the long-term administration of enalapril could be a possible risk factor for the disrupted distribution of those metal ions in biological systems.<br>","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"  Enalaprilat (H<sub>2</sub>L), which is the active metabolite of the pro-drug enalapril, is an angiotensin-converting enzyme inhibitor. Some side effects such as neurodegeneration and taste disorder can be related to copper or zinc deficiency, which would be caused by the metal complex formation of dianionic elalaprilat (L<sup>2−</sup>). For a better understanding of this phenomenon, we investigated the solution species of enalaprilat in the presence of copper(II) or zinc(II) ions by pH titration analysis with <i>I</i>=0.10 <small>M</small> (NaCl) at 25℃. The 1:1 complex formation constants (<i>K</i><sub>ML</sub>=[ML]/[M<sup>2+</sup>][L<sup>2−</sup>] <small>M</small><sup>−1</sup>) of 10<sup>7.4</sup> for CuL and 10<sup>4.4</sup> for ZnL complexes were evaluated, indicating the presence of those complexes at a physiological pH. Furthermore, partition experiments with a two-phase system of 1-butanol/water at 25℃ disclosed that copper(II) and zinc(II) complexes of enalaprilat were partially extracted into the organic layer. In the absence of those metal ions, enalaprilat was not soluble in the 1-butanol phase. The increase in lipophilicity of enalaprilat by metal complexation suggests that the long-term administration of enalapril could be a possible risk factor for the disrupted distribution of those metal ions in biological systems.<br>","subitem_description_type":"Other"}]},"item_10002_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"45631","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Fujioka, Haruto"}]},{"nameIdentifiers":[{"nameIdentifier":"45632","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hieda, Yuhzo"}]},{"nameIdentifiers":[{"nameIdentifier":"45633","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kuramoto, Yasuhiro"}]},{"nameIdentifiers":[{"nameIdentifier":"45634","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Konishi, Kanayo"}]},{"nameIdentifiers":[{"nameIdentifier":"45635","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kinoshita-Kikuta, Emiko"}]},{"nameIdentifiers":[{"nameIdentifier":"45636","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kinoshita, Eiji"}]},{"nameIdentifiers":[{"nameIdentifier":"45637","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Koike, Tohru"}]}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤岡, 晴人"}],"nameIdentifiers":[{"nameIdentifier":"45624","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"稗田, 雄三"}],"nameIdentifiers":[{"nameIdentifier":"45625","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"倉本, 康弘"}],"nameIdentifiers":[{"nameIdentifier":"45626","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西, 華那世"}],"nameIdentifiers":[{"nameIdentifier":"45627","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木下(菊田), 恵美子"}],"nameIdentifiers":[{"nameIdentifier":"45628","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木下, 英司"}],"nameIdentifiers":[{"nameIdentifier":"45629","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池, 透"}],"nameIdentifiers":[{"nameIdentifier":"45630","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-18"}],"displaytype":"detail","filename":"32-22.pdf","filesize":[{"value":"134.4 kB"}],"format":"application/pdf","license_note":"Copyright (c) 2014 by Fukuyama University","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"藤岡晴人(発表論文抄録(2013))","url":"https://fukuyama-u.repo.nii.ac.jp/record/8735/files/32-22.pdf"},"version_id":"3c826fde-85f7-4a45-acc1-d1026ca19095"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"angiotensin-converting enzyme inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"enalaprilat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"metal-ligand interaction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"metal deficiency","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"銅および亜鉛キレート形成によるACE阻害剤エナラプリラトの脂溶性増加(発表論文抄録(2013))","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"銅および亜鉛キレート形成によるACE阻害剤エナラプリラトの脂溶性増加(発表論文抄録(2013))"},{"subitem_title":"Increase in Lipophilicity of Enalaprilat by Complexation with Copper(II) or Zinc(II) Ions","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["782"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-18"},"publish_date":"2017-12-18","publish_status":"0","recid":"8735","relation_version_is_last":true,"title":["銅および亜鉛キレート形成によるACE阻害剤エナラプリラトの脂溶性増加(発表論文抄録(2013))"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:18:06.343154+00:00"}