{"created":"2023-06-19T09:51:32.546355+00:00","id":8732,"links":{},"metadata":{"_buckets":{"deposit":"3be0493e-2567-4736-b885-57cd7c0e9716"},"_deposit":{"created_by":18,"id":"8732","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8732"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008732","sets":["502:503:627:782"]},"author_link":["45538","45621","45620","45616","45615","45619","45617","45614","45618","45081","45075"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"32","bibliographicPageEnd":"19","bibliographicPageStart":"18","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"9,10-Phenanthrenequinone (9,10-PQ) is one of the most abundant quinones among diesel exhaust particulates. Recent data have suggested that quinones induce apoptosis in immune, epithelial and tumor cells, leading to respirator illness; however, the mechanisms by which quinones induce apoptosis and the structure required for this remain unknown. We studied the antitumor activity of 9,10-PQ analogs against two human tumor cell lines, HCT-116 colon tumor cells and HL-60 promyelocytic leukemia cells. The loss of the cis-orthoquinone unit in 9,10-PQ abrogated its ability to induce apoptosis in the two tumor cell lines, and the LC50 values of these analogs were indicated over 10 μM. An analog of 9,10-PQ in which the biaryl unit had been deleted displayed a reduced ability to induce tumor cell apoptosis, while the analogs 1,10-phenanthroline-5,6-dione (9) and pyrene-4,5-dione (10), which also had modified biaryl units, exhibited increased tumor cell apoptotic activity. The cis-orthoquinone unit in 9,10-PQ was identified as essential for its ability to induce apoptosis in tumor cells, and its biaryl unit is also considered to influence orthoquinone-mediated apoptotic activity.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"9,10-Phenanthrenequinone (9,10-PQ) is one of the most abundant quinones among diesel exhaust particulates. Recent data have suggested that quinones induce apoptosis in immune, epithelial and tumor cells, leading to respirator illness; however, the mechanisms by which quinones induce apoptosis and the structure required for this remain unknown. We studied the antitumor activity of 9,10-PQ analogs against two human tumor cell lines, HCT-116 colon tumor cells and HL-60 promyelocytic leukemia cells. The loss of the cis-orthoquinone unit in 9,10-PQ abrogated its ability to induce apoptosis in the two tumor cell lines, and the LC50 values of these analogs were indicated over 10 μM. An analog of 9,10-PQ in which the biaryl unit had been deleted displayed a reduced ability to induce tumor cell apoptosis, while the analogs 1,10-phenanthroline-5,6-dione (9) and pyrene-4,5-dione (10), which also had modified biaryl units, exhibited increased tumor cell apoptotic activity. The cis-orthoquinone unit in 9,10-PQ was identified as essential for its ability to induce apoptosis in tumor cells, and its biaryl unit is also considered to influence orthoquinone-mediated apoptotic activity.","subitem_description_type":"Other"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"波多江, 典之"}],"nameIdentifiers":[{"nameIdentifier":"45615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村, 純"}],"nameIdentifiers":[{"nameIdentifier":"45616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"奥島, 鉄雄"}],"nameIdentifiers":[{"nameIdentifier":"45617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石倉, 稔"}],"nameIdentifiers":[{"nameIdentifier":"45614","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000318134967","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000318134967"}]},{"creatorNames":[{"creatorName":"阿部, 匠"}],"nameIdentifiers":[{"nameIdentifier":"45538","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000248213387","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000248213387"}]},{"creatorNames":[{"creatorName":"日比野, 俐"}],"nameIdentifiers":[{"nameIdentifier":"45081","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014453717 ","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014453717 "}]},{"creatorNames":[{"creatorName":"町支, 臣成"}],"nameIdentifiers":[{"nameIdentifier":"45075","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005189344","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005189344"}]},{"creatorNames":[{"creatorName":"岡田, 知晃"}],"nameIdentifiers":[{"nameIdentifier":"45618","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 容子"}],"nameIdentifiers":[{"nameIdentifier":"45619","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000314064178","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000314064178"}]},{"creatorNames":[{"creatorName":"宇野, 英満"}],"nameIdentifiers":[{"nameIdentifier":"45620","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000018767432","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000018767432"}]},{"creatorNames":[{"creatorName":"豊田, 栄子"}],"nameIdentifiers":[{"nameIdentifier":"45621","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-18"}],"displaytype":"detail","filename":"32-18.pdf","filesize":[{"value":"185.4 kB"}],"format":"application/pdf","license_note":"Copyright (c) 2014 by Fukuyama University","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"波多江典之(発表論文抄録(2013))","url":"https://fukuyama-u.repo.nii.ac.jp/record/8732/files/32-18.pdf"},"version_id":"27e8f749-7dde-4329-aff4-a675baaba704"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Antineoplastic Agents","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Apoptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HCT116 Cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HL-60 Cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Inhibitory Concentration 50","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Molecular Structure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neoplasms","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Phenanthrenes","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"9,10-フェナンスリジン類によるHCT-116およびHL-60細胞のアポトーシスの誘導(発表論文抄録(2013))","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"9,10-フェナンスリジン類によるHCT-116およびHL-60細胞のアポトーシスの誘導(発表論文抄録(2013))"},{"subitem_title":"Effect of the orthoquinone moiety in 9,10-phenanthrenequinone on the ability to induce in HCT-116 and HL-60 cells.","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["782"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-18"},"publish_date":"2017-12-18","publish_status":"0","recid":"8732","relation_version_is_last":true,"title":["9,10-フェナンスリジン類によるHCT-116およびHL-60細胞のアポトーシスの誘導(発表論文抄録(2013))"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:18:11.792525+00:00"}