{"created":"2023-06-19T09:51:27.417044+00:00","id":8623,"links":{},"metadata":{"_buckets":{"deposit":"caa2c297-d95b-495e-91f1-4c876541917b"},"_deposit":{"created_by":18,"id":"8623","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8623"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008623","sets":["502:503:627:764"]},"author_link":["45400","45402","45399","45398","45401","45081","45075"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"29","bibliographicPageEnd":"30","bibliographicPageStart":"29","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy &   Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Nicotine has ameliorating effects on sensorimotor gating deficits in schizophrenia. We have shown that nicotine ameliorated disruption of prepulse inhibition (PPI) via the alpha(7) nicotinic acetylcholine receptor (nAChR) in Wistar rats. The 5-HT(3) receptor antagonist tropisetron was recently found to be an alpha(7) nAChR partial agonist. We initially investigated the effects of tropisetron on disruption of PPI induced by phencyclidine (PCP) (2mg/kg) or apomorphine (1mg/kg). Tropisetron had no effect on the disruption of PPI induced by PCP, but ameliorated the disruption by apomorphine. The ameliorating effect of tropisetron was antagonized by methyllycaconitine (2 or 5mg/kg), a partially selective alpha(7) nAChR antagonist. Next, to find the action site of tropisetron, we examined c-Fos protein expression in the nucleus accumbens (NAc), dorsolateral striatum (DLst) and ventral tegmental area (VTA). Tropisetron alone did not change the number of c-Fos-positive cells, whereas apomorphine increased the number of positive cells in the NAc and DLst. Tropisetron administration followed by apomorphine administration decreased the number of positive cells in the VTA compared with the apomorphine-alone group. These results suggest that tropisetron has an ameliorating effect on the sensorimotor gating deficits via the alpha(7) nAChR, and that one possible site of its action is the VTA.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Nicotine has ameliorating effects on sensorimotor gating deficits in schizophrenia. We have shown that nicotine ameliorated disruption of prepulse inhibition (PPI) via the alpha(7) nicotinic acetylcholine receptor (nAChR) in Wistar rats. The 5-HT(3) receptor antagonist tropisetron was recently found to be an alpha(7) nAChR partial agonist. We initially investigated the effects of tropisetron on disruption of PPI induced by phencyclidine (PCP) (2mg/kg) or apomorphine (1mg/kg). Tropisetron had no effect on the disruption of PPI induced by PCP, but ameliorated the disruption by apomorphine. The ameliorating effect of tropisetron was antagonized by methyllycaconitine (2 or 5mg/kg), a partially selective alpha(7) nAChR antagonist. Next, to find the action site of tropisetron, we examined c-Fos protein expression in the nucleus accumbens (NAc), dorsolateral striatum (DLst) and ventral tegmental area (VTA). Tropisetron alone did not change the number of c-Fos-positive cells, whereas apomorphine increased the number of positive cells in the NAc and DLst. Tropisetron administration followed by apomorphine administration decreased the number of positive cells in the VTA compared with the apomorphine-alone group. These results suggest that tropisetron has an ameliorating effect on the sensorimotor gating deficits via the alpha(7) nAChR, and that one possible site of its action is the VTA.","subitem_description_type":"Other"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鴻海, 俊太郎"}],"nameIdentifiers":[{"nameIdentifier":"45398","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006887089","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006887089"}]},{"creatorNames":[{"creatorName":"末丸, 克矢"}],"nameIdentifiers":[{"nameIdentifier":"45399","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002748576","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002748576"}]},{"creatorNames":[{"creatorName":"合田, 光寛"}],"nameIdentifiers":[{"nameIdentifier":"45400","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006490232","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006490232"}]},{"creatorNames":[{"creatorName":"町支, 臣成"}],"nameIdentifiers":[{"nameIdentifier":"45075","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005189344","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005189344"}]},{"creatorNames":[{"creatorName":"日比野, 俐"}],"nameIdentifiers":[{"nameIdentifier":"45081","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014453717 ","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014453717 "}]},{"creatorNames":[{"creatorName":"川崎, 博己"}],"nameIdentifiers":[{"nameIdentifier":"45401","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000060125151","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000060125151"}]},{"creatorNames":[{"creatorName":"荒木, 博陽"}],"nameIdentifiers":[{"nameIdentifier":"45402","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002460867","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002460867"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-08"}],"displaytype":"detail","filename":"Tropisetronはα7型ニコチン性アセチルコリン受容体を介してドパミン神経系が関与するprepulse情報処理障害を改善する.pdf","filesize":[{"value":"636.3 kB"}],"format":"application/pdf","license_note":"Copyright (c) 2011 by Fukuyama University\n","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Tropisetronはα7 型ニコチン性アセチルコリン受容  体を介してドパミン神経系が関与するprepulse 情報  処理障害を改善する","url":"https://fukuyama-u.repo.nii.ac.jp/record/8623/files/Tropisetronはα7型ニコチン性アセチルコリン受容体を介してドパミン神経系が関与するprepulse情報処理障害を改善する.pdf"},"version_id":"e9678c0e-e047-4a60-a297-a6dfec70a12b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Aconitine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Acoustic Stimulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Analysis of Variance","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Apomorphine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Brain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dopamine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dopamine Agonists","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dose-Response Relationship, Drug","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug Administration Schedule","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug Interactions","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Indoles","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Inhibition (Psychology)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mecamylamine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Models, Biological","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nicotinic Antagonists","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ondansetron","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Proto-Oncogene Proteins c-fos","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Psychoacoustics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rats","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rats, Wistar","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Receptors, Nicotinic","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Reflex, Startle","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Serotonin Antagonists","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Stereotyped Behavior","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"alpha7 Nicotinic Acetylcholine Receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Tropisetronはα7 型ニコチン性アセチルコリン受容体を介してドパミン神経系が関与するprepulse 情報処理障害を改善する(発表論文抄録（2010))","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tropisetronはα7 型ニコチン性アセチルコリン受容体を介してドパミン神経系が関与するprepulse 情報処理障害を改善する(発表論文抄録（2010))"},{"subitem_title":"Ameliorating effects of tropisetron on dopaminergic disruption of prepulse inhibition via the alpha(7) nicotinic acetylcholine receptor in Wistar rats.","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["764"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-02-08"},"publish_date":"2017-02-08","publish_status":"0","recid":"8623","relation_version_is_last":true,"title":["Tropisetronはα7 型ニコチン性アセチルコリン受容体を介してドパミン神経系が関与するprepulse 情報処理障害を改善する(発表論文抄録（2010))"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:20:19.092923+00:00"}