{"created":"2023-06-19T09:51:26.078874+00:00","id":8602,"links":{},"metadata":{"_buckets":{"deposit":"02d6c870-59dd-458f-82d6-6fdda219503f"},"_deposit":{"created_by":18,"id":"8602","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8602"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008602","sets":["502:503:627:763"]},"author_link":["45116","45341","45113","45117","45114"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"28","bibliographicPageEnd":"53","bibliographicPageStart":"53","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"通常飼料とCP飼料を12日間与えたラットの肝臓ではMPD(mevalonate pyrophosphate decarboxylase)は主にサイトゾルに局在するが、CP飼料(5%コレスチラミンと0.1%プラバスタチン)を与えたラットでは、少量のMPDがペルオキシソームに存在した。ロバスタチン処理および非処理のマウス黒色腫細胞(B16およびB16F10)におけるMPDの細胞内分布を、ジギトニン浸透法および免疫ブロット法により検討した。ロバスタチン処理後にジギトニンを浸透させたB16では、サイトゾルと膜/細胞小器官(M/O)分画それぞれにMPDの95%と5%が存在し、ロバスタチン非処理のB16では98%と2%が存在した。同条件下のB16F10では、MPDの80%と20%または91%と9%がそれぞれサイトゾルとM/O分画に存在した。これらの結果から、ロバスタチン処理/非処理のマウス黒色腫細胞では、MPDは主にサイトゾルに局在することが示された。","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"通常飼料とCP飼料を12日間与えたラットの肝臓ではMPD(mevalonate pyrophosphate decarboxylase)は主にサイトゾルに局在するが、CP飼料(5%コレスチラミンと0.1%プラバスタチン)を与えたラットでは、少量のMPDがペルオキシソームに存在した。ロバスタチン処理および非処理のマウス黒色腫細胞(B16およびB16F10)におけるMPDの細胞内分布を、ジギトニン浸透法および免疫ブロット法により検討した。ロバスタチン処理後にジギトニンを浸透させたB16では、サイトゾルと膜/細胞小器官(M/O)分画それぞれにMPDの95%と5%が存在し、ロバスタチン非処理のB16では98%と2%が存在した。同条件下のB16F10では、MPDの80%と20%または91%と9%がそれぞれサイトゾルとM/O分画に存在した。これらの結果から、ロバスタチン処理/非処理のマウス黒色腫細胞では、MPDは主にサイトゾルに局在することが示された。","subitem_description_type":"Other"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"道原, 明宏"}],"nameIdentifiers":[{"nameIdentifier":"45113","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014625611","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014625611"}]},{"creatorNames":[{"creatorName":"森田, 祥代"}],"nameIdentifiers":[{"nameIdentifier":"45341","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"戸田, 憲"}],"nameIdentifiers":[{"nameIdentifier":"45114","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014625939 ","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014625939 "}]},{"creatorNames":[{"creatorName":"赤崎, 健司"}],"nameIdentifiers":[{"nameIdentifier":"45116","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005185543","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005185543"}]},{"creatorNames":[{"creatorName":"辻, 宏"}],"nameIdentifiers":[{"nameIdentifier":"45117","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005185546","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005185546"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-28"}],"displaytype":"detail","filename":"ロバスタチンで処理したマウスメラノーマＢ１６とＢ１６Ｆ１０共に細胞質に多くメバロン酸二リン酸脱炭酸酵素が存在する.pdf","filesize":[{"value":"474.1 kB"}],"format":"application/pdf","license_note":"Copyright (c) 2010 by Fukuyama University","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ロバスタチンで処理したマウスメラノーマＢ１６とＢ１６Ｆ１０共に細胞質に多くメバロン酸二リン酸脱炭酸酵素が存在する","url":"https://fukuyama-u.repo.nii.ac.jp/record/8602/files/ロバスタチンで処理したマウスメラノーマＢ１６とＢ１６Ｆ１０共に細胞質に多くメバロン酸二リン酸脱炭酸酵素が存在する.pdf"},"version_id":"5c9735ff-5b42-4ec2-b6fa-34cd95053185"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"*Carboxy-Lyases","subitem_subject_scheme":"Other"},{"subitem_subject":"Cholesterol","subitem_subject_scheme":"Other"},{"subitem_subject":"*サイトゾル","subitem_subject_scheme":"Other"},{"subitem_subject":"*Lovastatin(薬理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"Melanins","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞小器官","subitem_subject_scheme":"Other"},{"subitem_subject":"*黒色腫(実験的)","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞膜","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍細胞系","subitem_subject_scheme":"Other"},{"subitem_subject":"*Diphosphomevalonate Decarboxylase","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"},{"subitem_subject":"*Carboxy-Lyases","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cholesterol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Melanins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"*Diphosphomevalonate Decarboxylase","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin 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