{"created":"2023-06-19T09:51:25.116944+00:00","id":8587,"links":{},"metadata":{"_buckets":{"deposit":"83052961-2a8e-4cc4-8636-5382bfc4817d"},"_deposit":{"created_by":18,"id":"8587","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8587"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008587","sets":["502:503:627:763"]},"author_link":["45287"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"28","bibliographicPageEnd":"34","bibliographicPageStart":"23","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"出血性脳障害についてトロンビン毒性を中心にさらなる解析を進め、得られた以下の知見について概説した。1)出血性脳障害におけるトロンビンおよびMAPキナーゼ経路の関与、2)トロンビン誘発活性化ミクログリアにおけるヘムオキシゲナーゼ-1の役割、3)ニコチン性アセチルコリン受容体の長期刺激によるトロンビン毒性の制御。出血に伴い脳実質中に漏出したトロンビンがMAPキナーゼ経路活性化を介してミクログリアの生存を維持しており、これが脳出血後の線条体ニューロン死に密接に関係している。","subitem_description_type":"Abstract"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大西, 正俊"}],"nameIdentifiers":[{"nameIdentifier":"45287","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-27"}],"displaytype":"detail","filename":"脳内出血病態形成におけるミクログリアの役割.pdf","filesize":[{"value":"5.8 MB"}],"format":"application/pdf","license_note":"Copyright (c) 2010 by Fukuyama University","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"脳内出血病態形成におけるミクログリアの役割","url":"https://fukuyama-u.repo.nii.ac.jp/record/8587/files/脳内出血病態形成におけるミクログリアの役割.pdf"},"version_id":"4b796bd9-7b78-4276-8323-f9b14b18d006"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"*Thrombin(薬理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"Nicotinic Receptors","subitem_subject_scheme":"Other"},{"subitem_subject":"*脳出血(実験的)","subitem_subject_scheme":"Other"},{"subitem_subject":"*ミクログリア","subitem_subject_scheme":"Other"},{"subitem_subject":"MAP Kinases","subitem_subject_scheme":"Other"},{"subitem_subject":"Heme Oxygenase-1","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"脳内出血病態形成におけるミクログリアの役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳内出血病態形成におけるミクログリアの役割"},{"subitem_title":"The role of microglia in hemorrhagic brain injury","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-01-27"},"publish_date":"2017-01-27","publish_status":"0","recid":"8587","relation_version_is_last":true,"title":["脳内出血病態形成におけるミクログリアの役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:21:02.822546+00:00"}