{"created":"2023-06-19T09:51:24.357263+00:00","id":8575,"links":{},"metadata":{"_buckets":{"deposit":"17978f7f-0edd-4bfb-bd7f-643c4164d186"},"_deposit":{"created_by":18,"id":"8575","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8575"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008575","sets":["502:503:627:762"]},"author_link":["45124","45166","45221","45220","45218","45222","45219","45217"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"27","bibliographicPageEnd":"45","bibliographicPageStart":"45","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Inhibition of protein oxidation by reactive oxygen species (ROS) would confer benefit to living organisms exposed to oxidative stress, because oxidized proteins are associated with many diseases and can propagate ROS-induced damage. We measured the ability of 2800Da chitosan, D-glucosamine and N-acetyl glucosamine to protect human serum albumin from oxidation by peroxyl radicals derived from 2,2'-azobis(2-amidinopropane)dihydrochloride and N-centered radicals from 1,1'-diphenyl-2-picrylhydrazyl and from 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid). Comparison with the antioxidant action of vitamin C showed that, on a molar basis, chitosan was equally effective in preventing formation of carbonyl and hydroperoxide groups in human serum albumin exposed to peroxyl radicals. It was also a potent inhibitor of conformational changes in the protein, assessed by absorption spectrum and intrinsic fluorescence. D-glucosamine was much less effective and N-acetyl glucosamine was not a useful antioxidant. Protection of the albumin from peroxyl radicals was achieved by scavenging of peroxyl radical. Chitosan was also a good scavenger of N-centered radicals, with glucosamine and N-acetyl glucosamine much less effective. The results suggest that administration of low molecular weight chitosans may inhibit neutrophil activation and oxidation of serum albumin commonly observed in patients undergoing hemodialysis, resulting in reduction of oxidative stress associated with uremia.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Inhibition of protein oxidation by reactive oxygen species (ROS) would confer benefit to living organisms exposed to oxidative stress, because oxidized proteins are associated with many diseases and can propagate ROS-induced damage. We measured the ability of 2800Da chitosan, D-glucosamine and N-acetyl glucosamine to protect human serum albumin from oxidation by peroxyl radicals derived from 2,2'-azobis(2-amidinopropane)dihydrochloride and N-centered radicals from 1,1'-diphenyl-2-picrylhydrazyl and from 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid). Comparison with the antioxidant action of vitamin C showed that, on a molar basis, chitosan was equally effective in preventing formation of carbonyl and hydroperoxide groups in human serum albumin exposed to peroxyl radicals. It was also a potent inhibitor of conformational changes in the protein, assessed by absorption spectrum and intrinsic fluorescence. D-glucosamine was much less effective and N-acetyl glucosamine was not a useful antioxidant. Protection of the albumin from peroxyl radicals was achieved by scavenging of peroxyl radical. Chitosan was also a good scavenger of N-centered radicals, with glucosamine and N-acetyl glucosamine much less effective. The results suggest that administration of low molecular weight chitosans may inhibit neutrophil activation and oxidation of serum albumin commonly observed in patients undergoing hemodialysis, resulting in reduction of oxidative stress associated with uremia.","subitem_description_type":"Other"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0141-8130","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"安楽, 誠"}],"nameIdentifiers":[{"nameIdentifier":"45124","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000003077192","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000003077192"}]},{"creatorNames":[{"creatorName":"樺島, 三樹絵"}],"nameIdentifiers":[{"nameIdentifier":"45219","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"苗村, ひとみ"}],"nameIdentifiers":[{"nameIdentifier":"45220","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丸山, 徹"}],"nameIdentifiers":[{"nameIdentifier":"45217","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002749091","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002749091"}]},{"creatorNames":[{"creatorName":"小田切, 優樹"}],"nameIdentifiers":[{"nameIdentifier":"45218","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000080120145","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000080120145"}]},{"creatorNames":[{"creatorName":"Gebicki, Janusz M"}],"nameIdentifiers":[{"nameIdentifier":"45221","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000337100410","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000337100410"}]},{"creatorNames":[{"creatorName":"古谷, 暢子"}],"nameIdentifiers":[{"nameIdentifier":"45222","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014200260","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014200260"}]},{"creatorNames":[{"creatorName":"冨田, 久夫"}],"nameIdentifiers":[{"nameIdentifier":"45166","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005174459","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005174459"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-27"}],"displaytype":"detail","filename":"45安楽.pdf","filesize":[{"value":"51.6 kB"}],"format":"application/pdf","license_note":"Copyright (c) 2009 by Fukuyama University","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"キトサンのヒト血清アルブミンに対する抗酸化作用","url":"https://fukuyama-u.repo.nii.ac.jp/record/8575/files/45安楽.pdf"},"version_id":"8a9100a3-bcbb-41f0-be8f-ec384b7f272f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Ascorbic Acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chitosan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fluorometry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Free Radical Scavengers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidation-Reduction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidative Stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Reactive Oxygen Species","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Serum Albumin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Spectrophotometry, Ultraviolet","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"キトサンのヒト血清アルブミンに対する抗酸化作用(発表論文抄録(2008))","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"キトサンのヒト血清アルブミンに対する抗酸化作用(発表論文抄録(2008))"},{"subitem_title":"Antioxidant protection of human serum albumin by chitosan.","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["762"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-01-27"},"publish_date":"2017-01-27","publish_status":"0","recid":"8575","relation_version_is_last":true,"title":["キトサンのヒト血清アルブミンに対する抗酸化作用(発表論文抄録(2008))"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:21:17.059100+00:00"}