{"created":"2023-06-19T09:51:24.041478+00:00","id":8570,"links":{},"metadata":{"_buckets":{"deposit":"2d4dfc01-379a-43af-a981-4d509dd8ee89"},"_deposit":{"created_by":18,"id":"8570","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8570"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008570","sets":["502:503:627:762"]},"author_link":["45123","45121","45199","45200","45118"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"27","bibliographicPageEnd":"38","bibliographicPageStart":"38","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The accumulation of (-)-epicatechin (EC), a non-gallate catechin, was significantly lower than that of (-)-epicatechin gallate (ECG), a gallate catechin, in Caco-2 cells. Using Caco-2 cell monolayers cultured in transwells, the transport of catechins in the basolateral-to-apical direction was much higher than that in the apical-to-basolateral direction, suggesting the involvement of an efflux transporter. Moreover, the results suggest that involvement of a transporter in EC efflux is greater than that for ECG. Treatment with transporter inhibitors MK571, quinidine or mitoxantrone, which inhibit MRP2, P-glycoprotein (P-gp) and BCRP, respectively, led to an increase in the accumulation of EC into Caco-2 cells and a decrease in the Papp ratio (Papp B-->A/Papp A-->B) for EC. These transporters seemed to be involved in EC efflux. BCRP was not an efflux transporter for ECG, and the influences of MRP2 and P-gp on ECG efflux were lower than for EC. Thus, efflux transporters appear to be responsible for the difference in cellular accumulation of EC versus ECG, suggesting that the presence or absence of a gallate moiety in the catechin structure influences the transporters.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The accumulation of (-)-epicatechin (EC), a non-gallate catechin, was significantly lower than that of (-)-epicatechin gallate (ECG), a gallate catechin, in Caco-2 cells. Using Caco-2 cell monolayers cultured in transwells, the transport of catechins in the basolateral-to-apical direction was much higher than that in the apical-to-basolateral direction, suggesting the involvement of an efflux transporter. Moreover, the results suggest that involvement of a transporter in EC efflux is greater than that for ECG. Treatment with transporter inhibitors MK571, quinidine or mitoxantrone, which inhibit MRP2, P-glycoprotein (P-gp) and BCRP, respectively, led to an increase in the accumulation of EC into Caco-2 cells and a decrease in the Papp ratio (Papp B-->A/Papp A-->B) for EC. These transporters seemed to be involved in EC efflux. BCRP was not an efflux transporter for ECG, and the influences of MRP2 and P-gp on ECG efflux were lower than for EC. Thus, efflux transporters appear to be responsible for the difference in cellular accumulation of EC versus ECG, suggesting that the presence or absence of a gallate moiety in the catechin structure influences the transporters.","subitem_description_type":"Other"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"門脇, 正明"}],"nameIdentifiers":[{"nameIdentifier":"45121","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014625941","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014625941"}]},{"creatorNames":[{"creatorName":"杉原, 成美"}],"nameIdentifiers":[{"nameIdentifier":"45118","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005187246","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005187246"}]},{"creatorNames":[{"creatorName":"田頭, 知彦"}],"nameIdentifiers":[{"nameIdentifier":"45199","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"寺尾, 和美"}],"nameIdentifiers":[{"nameIdentifier":"45200","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000337100387","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000337100387"}]},{"creatorNames":[{"creatorName":"古野, 浩二"}],"nameIdentifiers":[{"nameIdentifier":"45123","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005185545","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005185545"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-26"}],"displaytype":"detail","filename":"38門脇.pdf","filesize":[{"value":"63.2 kB"}],"format":"application/pdf","license_note":"Copyright (c) 2009 by Fukuyama University","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"カチキン類の細胞透過に及ぼすカテキン構造中のガレート基の影響","url":"https://fukuyama-u.repo.nii.ac.jp/record/8570/files/38門脇.pdf"},"version_id":"0bc16461-755e-49bb-942c-0a0f6ade77ba"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ATP Binding Cassette Transporter, Sub-Family G, Member 2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ATP-Binding Cassette Transporters","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Biological Transport","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Caco-2 Cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Catechin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Multidrug Resistance-Associated Proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neoplasm Proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"P-Glycoprotein","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"カチキン類の細胞透過に及ぼすカテキン構造中のガレート基の影響(発表論文抄録(2008))","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"カチキン類の細胞透過に及ぼすカテキン構造中のガレート基の影響(発表論文抄録(2008))"},{"subitem_title":"Presence or absence of a gallate moiety on catechins affects their cellular transport.","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["762"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-01-26"},"publish_date":"2017-01-26","publish_status":"0","recid":"8570","relation_version_is_last":true,"title":["カチキン類の細胞透過に及ぼすカテキン構造中のガレート基の影響(発表論文抄録(2008))"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:21:22.886494+00:00"}