{"created":"2023-06-19T09:51:22.648055+00:00","id":8544,"links":{},"metadata":{"_buckets":{"deposit":"987d3765-0e0d-4d37-90f5-fc58a4a09303"},"_deposit":{"created_by":18,"id":"8544","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8544"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008544","sets":["502:503:627:761"]},"author_link":["45124","45131","45137","45141","45138","45136","45129","45140","45139"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"26","bibliographicPageEnd":"61","bibliographicPageStart":"61","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effect of olmesartan, an inverse angiotensin II type 1 receptor blocker (ARB), on oxidative stress in hemodialysis (HD) patients is not fully understood, and has not been widely investigated in vitro or in vivo. We determined the amount of oxidized albumin and albumin hydroperoxides formed during incubation in the absence and presence of olmesartan by high-performance liquid chromatography (HPLC) and by a ferrous oxidation xylenol assay in an in vitro study. Six hypertensive HD patients were treated with 40 mg of olmesartan once daily, and blood pressure monitoring (BPM) was performed after 0, 4, and 8 weeks of treatment. The ratio of oxidized to unoxidized albumin was also determined. The oxidized albumin ratios and levels of albumin hydroperoxides were significantly decreased in a concentration-dependent manner in the presence of olmesartan, compared with the absence of olmesartan (p<0.05) in in vitro studies. In HD patients, olmesartan also significantly reduced systolic and diastolic blood pressure after 4 weeks, with a further significant decrease after 8 weeks. The ratio of oxidized to unoxidized albumin was markedly decreased after 4 weeks and these lower levels were maintained at 8 weeks. Olmesartan effectively lowered the extent of oxidation of albumin in both in vitro and in vivo studies, and this effect might confer benefits beyond a reduction in blood pressure.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The effect of olmesartan, an inverse angiotensin II type 1 receptor blocker (ARB), on oxidative stress in hemodialysis (HD) patients is not fully understood, and has not been widely investigated in vitro or in vivo. We determined the amount of oxidized albumin and albumin hydroperoxides formed during incubation in the absence and presence of olmesartan by high-performance liquid chromatography (HPLC) and by a ferrous oxidation xylenol assay in an in vitro study. Six hypertensive HD patients were treated with 40 mg of olmesartan once daily, and blood pressure monitoring (BPM) was performed after 0, 4, and 8 weeks of treatment. The ratio of oxidized to unoxidized albumin was also determined. The oxidized albumin ratios and levels of albumin hydroperoxides were significantly decreased in a concentration-dependent manner in the presence of olmesartan, compared with the absence of olmesartan (p<0.05) in in vitro studies. In HD patients, olmesartan also significantly reduced systolic and diastolic blood pressure after 4 weeks, with a further significant decrease after 8 weeks. The ratio of oxidized to unoxidized albumin was markedly decreased after 4 weeks and these lower levels were maintained at 8 weeks. Olmesartan effectively lowered the extent of oxidation of albumin in both in vitro and in vivo studies, and this effect might confer benefits beyond a reduction in blood pressure.","subitem_description_type":"Other"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"門脇, 大介"}],"nameIdentifiers":[{"nameIdentifier":"45137","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000070433000","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"安楽, 誠"}],"nameIdentifiers":[{"nameIdentifier":"45124","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000003077192","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000003077192"}]},{"creatorNames":[{"creatorName":"田先, 由佳"}],"nameIdentifiers":[{"nameIdentifier":"45138","nameIdentifierScheme":"WEKO"},{"nameIdentifier":" 9000283797567","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/ 9000283797567"}]},{"creatorNames":[{"creatorName":"北村, 健一郎"}],"nameIdentifiers":[{"nameIdentifier":"45131","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014554432","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014554432"}]},{"creatorNames":[{"creatorName":"若松, 志保"}],"nameIdentifiers":[{"nameIdentifier":"45139","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014625989","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014625989"}]},{"creatorNames":[{"creatorName":"冨田, 公夫"}],"nameIdentifiers":[{"nameIdentifier":"45140","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000020411356","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000020411356"}]},{"creatorNames":[{"creatorName":"Gebicki, Janusz M"}],"nameIdentifiers":[{"nameIdentifier":"45141","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000001980702 ","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000001980702 "}]},{"creatorNames":[{"creatorName":"丸山, 徹"}],"nameIdentifiers":[{"nameIdentifier":"45136","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090423657","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"小田切, 優樹"}],"nameIdentifiers":[{"nameIdentifier":"45129","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014580888","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014580888"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-11-30"}],"displaytype":"detail","filename":"61 オルメサルタンの透析患者.pdf","filesize":[{"value":"125.3 kB"}],"format":"application/pdf","license_note":"Copyright (c) 2008 by Fukuyama University","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"オルメサルタンの透析患者における酸化ストレスに及ぼす影響","url":"https://fukuyama-u.repo.nii.ac.jp/record/8544/files/61 オルメサルタンの透析患者.pdf"},"version_id":"71682a09-cf86-4070-bded-d6c70f7556ce"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adult","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Aged","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Aged, 80 and over","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Angiotensin II Type 1 Receptor Blockers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Antioxidants","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Blood Pressure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Female","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hypertension, Renal","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Imidazoles","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Kidney Failure, Chronic","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Middle Aged","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidative Stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Peroxides","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Placebos","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Renal Dialysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Serum Albumin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tetrazoles","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Uremia","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"オルメサルタンの透析患者における酸化ストレスに及ぼす影響(発表論文抄録(2007))","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"オルメサルタンの透析患者における酸化ストレスに及ぼす影響(発表論文抄録(2007))"},{"subitem_title":"Effect of olmesartan on oxidative stress in hemodialysis patients.","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["761"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-11-30"},"publish_date":"2016-11-30","publish_status":"0","recid":"8544","relation_version_is_last":true,"title":["オルメサルタンの透析患者における酸化ストレスに及ぼす影響(発表論文抄録(2007))"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:21:51.746305+00:00"}