{"created":"2023-06-19T09:51:22.521137+00:00","id":8542,"links":{},"metadata":{"_buckets":{"deposit":"cfeba0bf-c248-4887-ada7-4837f72b97cf"},"_deposit":{"created_by":18,"id":"8542","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8542"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008542","sets":["502:503:627:761"]},"author_link":["45124","45127","45126","45128","45129","45125"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"26","bibliographicPageEnd":"59","bibliographicPageStart":"59","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Sodium octanoate (Oct) and N-acetyl-l-tryptophanate (N-AcTrp) are widely used as stabilizers during the pasteurization of albumin products. However, N-AcTrp has a possible side effect of intracerebral disease. To provide safe and risk-free albumin products, we validated N-acetyl-methioninate (N-AcMet) as a new stabilizer for albumin products. The effect of N-AcMet on oxidation was examined using 2,2'-azobis(2-amidino-propane) dihydrochloride (AAPH) as an oxidizing agent. Carbonyl content in the presence of N-AcMet, as well as that in the presence of N-AcTrp after 24h (Anraku et al., 2004), was significantly decreased. The effect of AAPH on the oxidative status of 34-Cys on human serum albumin was also studied by HPLC. It was found that N-AcMet as well as N-AcTrp, has a large protective effect on the sulfhydryl group after 1h. Further, N-AcMet was found to be a superior radical scavenger to N-AcTrp using 1,1'-diphenyl-2-picrylhydrazyl (DPPH) radicals. The thermal stabilizing role of N-AcMet manifested as an increase in denaturation temperature and calorimetric enthalpy, as determined by differential scanning calorimetry (DSC). In the present study, we suggest that use of N-AcMet in albumin preparation is safe and free of risk of side effects.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Sodium octanoate (Oct) and N-acetyl-l-tryptophanate (N-AcTrp) are widely used as stabilizers during the pasteurization of albumin products. However, N-AcTrp has a possible side effect of intracerebral disease. To provide safe and risk-free albumin products, we validated N-acetyl-methioninate (N-AcMet) as a new stabilizer for albumin products. The effect of N-AcMet on oxidation was examined using 2,2'-azobis(2-amidino-propane) dihydrochloride (AAPH) as an oxidizing agent. Carbonyl content in the presence of N-AcMet, as well as that in the presence of N-AcTrp after 24h (Anraku et al., 2004), was significantly decreased. The effect of AAPH on the oxidative status of 34-Cys on human serum albumin was also studied by HPLC. It was found that N-AcMet as well as N-AcTrp, has a large protective effect on the sulfhydryl group after 1h. Further, N-AcMet was found to be a superior radical scavenger to N-AcTrp using 1,1'-diphenyl-2-picrylhydrazyl (DPPH) radicals. The thermal stabilizing role of N-AcMet manifested as an increase in denaturation temperature and calorimetric enthalpy, as determined by differential scanning calorimetry (DSC). In the present study, we suggest that use of N-AcMet in albumin preparation is safe and free of risk of side effects.","subitem_description_type":"Other"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"福山大学薬学部"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"安楽, 誠"}],"nameIdentifiers":[{"nameIdentifier":"45124","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000003077192","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000003077192"}]},{"creatorNames":[{"creatorName":"河野, 陽介"}],"nameIdentifiers":[{"nameIdentifier":"45125","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"甲斐, 俊哉"}],"nameIdentifiers":[{"nameIdentifier":"45126","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000005190005","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000005190005"}]},{"creatorNames":[{"creatorName":"鶴崎, 泰史"}],"nameIdentifiers":[{"nameIdentifier":"45127","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006820332 ","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006820332 "}]},{"creatorNames":[{"creatorName":"山崎, 啓之"}],"nameIdentifiers":[{"nameIdentifier":"45128","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000253263467","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000253263467"}]},{"creatorNames":[{"creatorName":"小田切, 優樹"}],"nameIdentifiers":[{"nameIdentifier":"45129","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014580888","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014580888"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-11-30"}],"displaytype":"detail","filename":"59 アルブミン製剤におけるＮ－アセチル－メチオニンの.pdf","filesize":[{"value":"130.1 kB"}],"format":"application/pdf","license_note":"Copyright (c) 2008 by Fukuyama University","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"アルブミン製剤におけるＮ－アセチル－メチオニンの新規添加剤としての役割","url":"https://fukuyama-u.repo.nii.ac.jp/record/8542/files/59 アルブミン製剤におけるＮ－アセチル－メチオニンの.pdf"},"version_id":"1733f8b1-cd24-4bd6-b58e-393a95c49f93"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Drug Stability","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ligands","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Methionine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidation-Reduction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Serum Albumin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"アルブミン製剤におけるＮ－アセチル－メチオニンの新規添加剤としての役割(発表論文抄録(2007))","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アルブミン製剤におけるＮ－アセチル－メチオニンの新規添加剤としての役割(発表論文抄録(2007))"},{"subitem_title":"The role of N-acetyl-methioninate as a new stabilizer for albumin products.","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["761"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-11-30"},"publish_date":"2016-11-30","publish_status":"0","recid":"8542","relation_version_is_last":true,"title":["アルブミン製剤におけるＮ－アセチル－メチオニンの新規添加剤としての役割(発表論文抄録(2007))"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-06-19T10:21:54.364455+00:00"}