{"created":"2023-06-19T09:51:22.072820+00:00","id":8535,"links":{},"metadata":{"_buckets":{"deposit":"c22d1050-ddf4-4131-85df-cdb16d3fb47c"},"_deposit":{"created_by":18,"id":"8535","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8535"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00008535","sets":["502:503:627:761"]},"author_link":["45092","45081","45084","45090","45094","45083","45075","45086","45085","45093","45091","45082","45088","45087","45089"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"26","bibliographicPageEnd":"49","bibliographicPageStart":"48","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The enhancement of intracellular stresses such as oxidative stress and endoplasmic reticulum (ER) stress has been implicated in several neurodegenerative disorders including Parkinson's disease (PD). During a search for compounds that regulate ER stress, a dibenzoylmethane (DBM) derivative 14-26 (2,2'-dimethoxydibenzoylmethane) was identified as a novel neuroprotective agent. Analysis in SH-SY5Y cells and in PC12 cells revealed that the regulation of ER stress by 14-26 was associated with its anti-oxidative property. 14-26 prevented the production of reactive oxygen species (ROS) when the cells were exposed to oxidants such as hydrogen peroxide and 6-hydroxydopamine (6-OHDA) or an ER stressor brefeldin A (BFA). 14-26 also prevented ROS-induced damage in both the ER and the mitochondria, including the protein carbonylation in the microsome and the reduction of the mitochondrial membrane potential. Further examination disclosed the presence of the iron-chelating activity in 14-26. In vivo, 14-26 suppressed both oxidative stress and ER stress and prevented neuronal death in the substantia nigra pars compacta (SNpc) after injection of 6-OHDA in mice. These results suggest that 14-26 is an antioxidant that protects dopaminergic neurons against both oxidative stress and ER stress and could be a therapeutic candidate for the treatment of PD.","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The enhancement of intracellular stresses such as oxidative stress and endoplasmic reticulum (ER) stress has been implicated in several neurodegenerative disorders including Parkinson's disease (PD). During a search for compounds that regulate ER stress, a dibenzoylmethane (DBM) derivative 14-26 (2,2'-dimethoxydibenzoylmethane) was identified as a novel neuroprotective agent. Analysis in SH-SY5Y cells and in PC12 cells revealed that the regulation of ER stress by 14-26 was associated with its anti-oxidative property. 14-26 prevented the production of reactive oxygen species (ROS) when the cells were exposed to oxidants such as hydrogen peroxide and 6-hydroxydopamine (6-OHDA) or an ER stressor brefeldin A (BFA). 14-26 also prevented ROS-induced damage in both the ER and the mitochondria, including the protein carbonylation in the microsome and the reduction of the mitochondrial membrane potential. Further examination disclosed the presence of the iron-chelating activity in 14-26. In vivo, 14-26 suppressed both oxidative stress and ER stress and prevented neuronal death in the substantia nigra pars compacta (SNpc) after injection of 6-OHDA in mice. These results suggest that 14-26 is an antioxidant that protects dopaminergic neurons against both oxidative stress and ER stress and could be a therapeutic candidate for the treatment of PD.","subitem_description_type":"Other"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-724X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高野, 桂"}],"nameIdentifiers":[{"nameIdentifier":"45082","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000001196445","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000001196445"}]},{"creatorNames":[{"creatorName":"北尾, 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Expression","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mice, Inbred ICR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mitochondria","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neurons","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neuroprotective Agents","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidative Stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidopamine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PC12 Cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Parkinson Disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rats","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Reactive Oxygen Species","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Substantia Nigra","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sympatholytics","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin 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