{"created":"2023-06-19T09:50:59.908519+00:00","id":7970,"links":{},"metadata":{"_buckets":{"deposit":"9d6d295b-8d98-4477-80eb-d0bfb90615d2"},"_deposit":{"created_by":3,"id":"7970","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"7970"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00007970","sets":["502:505:675:698:700"]},"author_link":["42830","42829","42826","42831","42828","42827"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"69","bibliographicPageStart":"61","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"福山大学工学部紀要"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"楠瀬, 正道"}],"nameIdentifiers":[{"nameIdentifier":"42826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊田, 安至"}],"nameIdentifiers":[{"nameIdentifier":"42827","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"We have isolated and sequenced cDNAs encoding two human leukotriene B_4 (LTB_4) ω-hydroxylases. Human neutrophil enzyme (CYP4F3) contained 520 amino acids with a molecular weight of 59,805 Da, while human liver enzyme (CYP4F2) contained 520 amino acids with a molecular weight of 59,853 Da. The two enzymes showed 87.3% sequence homology with each other. The microsomes from yeast cells transfected with the cDNAs for CYP4F3 and CYP4F2 catalyzed the ω-hydroxylation of LTB_4 with Km values of 0.71μM and 46μM, respectively. Highly purified enzyme of CYP4F3 also exhibited ω-hydroxylase activities toward LTB_4, 6-trans-LTB_4, 20-hydroxy LTB_4, lipoxin A_4, lipoxin B_4, and 12-HETE. Sourthern blot of human genomic DNA probed with the CYP4F3 cDNA indicated the existence of at least 5 related genes of CYP4F. The CYP4F3 gene, which contained 12 exons, was mapped to chromosome 19p13.2.","subitem_description_type":"Other"}]},"item_1_full_name_7":{"attribute_name":"著者名よみ","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"42828","nameIdentifierScheme":"WEKO"}],"names":[{"name":"クスノセ, マサミチ"}]},{"nameIdentifiers":[{"nameIdentifier":"42829","nameIdentifierScheme":"WEKO"}],"names":[{"name":"キクタ, ヤスシ"}]}]},"item_1_full_name_8":{"attribute_name":"著者名(英)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"42830","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KUSUNOSE, Masamichi","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"42831","nameIdentifierScheme":"WEKO"}],"names":[{"name":"KIKUTA, Yasushi","nameLang":"en"}]}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00217655","subitem_source_identifier_type":"NCID"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"福山大学工学部食品工学科"},{"subitem_text_value":"福山大学工学部食品工学科"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1996-03-01"}],"displaytype":"detail","filename":"KJ00005781369.pdf","filesize":[{"value":"793.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://fukuyama-u.repo.nii.ac.jp/record/7970/files/KJ00005781369.pdf"},"version_id":"547d58df-a1cb-4e7b-93d2-ded1343ca688"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脂肪酸ω水酸化酵素","subitem_subject_scheme":"Other"},{"subitem_subject":"チトクロームP450","subitem_subject_scheme":"Other"},{"subitem_subject":"ロイコトリエンB_4ω水酸化酵素","subitem_subject_scheme":"Other"},{"subitem_subject":"CYP4F","subitem_subject_scheme":"Other"},{"subitem_subject":"cDNA","subitem_subject_scheme":"Other"},{"subitem_subject":"クローニング","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"染色体","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ロイコトリエンB_4ω水酸化酵素の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ロイコトリエンB_4ω水酸化酵素の研究"},{"subitem_title":"Studies on Leukotriene B_4 ω-Hydroxylase","subitem_title_language":"en"}]},"item_type_id":"1","owner":"3","path":["700"],"pubdate":{"attribute_name":"公開日","attribute_value":"1996-03-01"},"publish_date":"1996-03-01","publish_status":"0","recid":"7970","relation_version_is_last":true,"title":["ロイコトリエンB_4ω水酸化酵素の研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T10:33:03.066860+00:00"}