@article{oai:fukuyama-u.repo.nii.ac.jp:00007515,
 journal = {福山大学生命工学部研究年報, Annual report of Faculty of Life Science and Biotechnology, Fukuyama University},
 month = {Sep},
 note = {P(論文), The structural changes of DNA caused by PtCl_2(diaminocyclohexane (DACH)) were observed by an atomic force microscope (AFM). The AFM image of pUC19 DNA treated by Eco RI show that the DNA is shaped like a string. The AFM image of DNA treated with PtCl_2(DACH) at a ratio of platinum compound / base pair (r)=1.0 or 0.1 is very different from that of DNA and shows an ellipsoidal sphere in which the string of DNA was rolled up. The DNA treated with PtCl_2(DACH) at the ratio of platinum compound / base pair (r)=0.01 is also shaped into a ball, but the diameter of the ball is larger than that treated with PtCl_2(DACH) at the ratio of platinum compound / base pair (r)=1 or 0.1. It is known that, when the platinum complex binds to the double helix of DNA, a kink occurs in the DNA. The dramatic changes of the shape of the DNA from a string to a sphere were occurred by accumulating the DNA kink induced by the platinum complex.},
 pages = {11--15},
 title = {The Interaction of Oxaliplatin(Pt(oxalate)(1R, 2R-cyclohexanediamine)) with DNA Visualized by an Atomic Force Microscope},
 volume = {5},
 year = {2006}
}