{"created":"2023-06-19T09:50:35.740253+00:00","id":7505,"links":{},"metadata":{"_buckets":{"deposit":"81f7bc3f-0a2d-49f6-b8c8-dfd16c29d8df"},"_deposit":{"created_by":3,"id":"7505","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"7505"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00007505","sets":["502:506:662:666"]},"author_link":["41158","41155","41151","41150","41157","41153","41154","41152","41156"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-09","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"9","bibliographicPageStart":"1","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"福山大学生命工学部研究年報"},{"bibliographic_title":"Annual report of Faculty of Life Science and Biotechnology, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井上, 忠雄"}],"nameIdentifiers":[{"nameIdentifier":"41150","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青島, 園子"}],"nameIdentifiers":[{"nameIdentifier":"41151","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山口, 泰典"}],"nameIdentifiers":[{"nameIdentifier":"41152","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"Hsp90はHeat shock proteinファミリーの一員であり、その分子シャペロンとしての機能は種を越えて良く保存されている。これまでの研究により、多くのタンパク質がその立体構造保持のために、Hsp90の機能を必要とすることが明らかとなっているが、多細胞生物におけるHsp90の機能喪失が細胞や組織の機能に与える影響という観点からの解析はあまり例を見ない。この度、われわれは線虫C. elegansにおける、Hsp90ホモログであるDAF-21の機能がその遺伝子変異及びRNAiにより低下することにより、生体内において生殖巣の形成を誘導するリーダー細胞の移動方向及び移動そのものに影響を与えること、雌雄同体の産卵口の形成、並びに雄尾部交尾器の形成に異常を示すことを見い出した。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Hsp90 is one of the major heat shock protein families and is known to chaperone various kinds of target proteins during normal development. Although many client proteins that require the function of Hsp90 have been identified, the effect of Hsp90 impairment for cellular function is poorly understood. We here describe that a novel phenotype for daf-21 (C. elegans Hsp90) mutant strain, which showed the following abnormalities; 1) distal tip cells (DTCs) migration defect, 2) vulval development defect, and 3) male tail morphological defect. Whereas DTC migration defect was observed in both daf-21 (p673) mutant strain and daf-21 (RNAi) animals, the latter two defects were only seen in daf-21 (RNAi) animals. Together, DAF-21/Hsp90 plays multiple roles during somatic lineage development.","subitem_description_type":"Other"}]},"item_1_full_name_7":{"attribute_name":"著者名よみ","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"41153","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イノウエ, タダオ"}]},{"nameIdentifiers":[{"nameIdentifier":"41154","nameIdentifierScheme":"WEKO"}],"names":[{"name":"アオシマ, ソノコ"}]},{"nameIdentifiers":[{"nameIdentifier":"41155","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヤマグチ, ヤスノリ"}]}]},"item_1_full_name_8":{"attribute_name":"著者名(英)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"41156","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Inoue, Tadao","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"41157","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Aoshima, Sonoko","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"41158","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yamaguchi, Yasunori","nameLang":"en"}]}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11870542","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Biotechnology, Faculty of Life Science and Biotechnology, Fukuyama University"},{"subitem_text_language":"en","subitem_text_value":"Department of Biotechnology, Faculty of Life Science and Biotechnology, Fukuyama University"},{"subitem_text_language":"en","subitem_text_value":"Department of Biotechnology, Faculty of Life Science and Biotechnology, Fukuyama University"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"福山大学生命工学部生物工学科"},{"subitem_text_value":"福山大学生命工学部生物工学科"},{"subitem_text_value":"福山大学生命工学部生物工学科"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2005-09-01"}],"displaytype":"detail","filename":"KJ00005782181.pdf","filesize":[{"value":"781.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://fukuyama-u.repo.nii.ac.jp/record/7505/files/KJ00005782181.pdf"},"version_id":"f2e58e5c-bc4e-4775-9503-7c49442a4b32"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"DAF-21","subitem_subject_scheme":"Other"},{"subitem_subject":"Hsp90","subitem_subject_scheme":"Other"},{"subitem_subject":"C. elegans","subitem_subject_scheme":"Other"},{"subitem_subject":"RNAi","subitem_subject_scheme":"Other"},{"subitem_subject":"DTCs","subitem_subject_scheme":"Other"},{"subitem_subject":"DAF-21","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hsp90","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"C. elegans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"RNAi","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DTCs","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"線虫C. elegans daf-21/Hsp90異常の体細胞分化への影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"線虫C. elegans daf-21/Hsp90異常の体細胞分化への影響"},{"subitem_title":"Identification of somatic phenotypes caused by daf-21/Hsp90 mutation in Caenorhabditis elegans","subitem_title_language":"en"}]},"item_type_id":"1","owner":"3","path":["666"],"pubdate":{"attribute_name":"公開日","attribute_value":"2005-09-01"},"publish_date":"2005-09-01","publish_status":"0","recid":"7505","relation_version_is_last":true,"title":["線虫C. elegans daf-21/Hsp90異常の体細胞分化への影響"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T10:41:50.179083+00:00"}