@article{oai:fukuyama-u.repo.nii.ac.jp:00007360,
 author = {宇野, 勝次},
 journal = {福山大学薬学部研究年報, Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University},
 month = {},
 note = {P(論文), Drug hypersensitivity includes an allergic and pseudoallergic reaction to drug. Therefore, the pathogenic mechanism of drug hypersensitivity must be studied from two viewpoints of immunological reaction and pharmacological reaction. And it is necessary for the mechanism of drug allergy to be investigated m three phases, that is, an antigen formation, an immune reaction and an inflammatory reaction. Particularly, cytokines take an important part in the development of drug allergy. Besides, the cross-reactivity of β-lactam antibiotics in allergic reaction constitutes a serious problem on the secondary choice of antibiotics for the patients with allergy to β-lactam antibiotics. Then, I review the participation of cytokines in drug allergy, the cross-reactivity of β-lactam antibiotics in allergic reaction and further the pseudoallergic reaction to drug.},
 pages = {1--20},
 title = {薬物過敏症の発症機序に関する研究},
 volume = {25},
 year = {2007}
}