{"created":"2023-06-19T09:50:28.244288+00:00","id":7328,"links":{},"metadata":{"_buckets":{"deposit":"eb69c5e4-a752-481b-8769-823869ec7782"},"_deposit":{"created_by":3,"id":"7328","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"7328"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00007328","sets":["502:503:627:651"]},"author_link":["39699","39698","39705","39703","39704","39707","39706","39700","39702","39708","39697","39701"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"23","bibliographicPageStart":"1","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田頭, 尚士"}],"nameIdentifiers":[{"nameIdentifier":"39697","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"螻川内, 理恵"}],"nameIdentifiers":[{"nameIdentifier":"39698","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"本屋敷, 敏雄"}],"nameIdentifiers":[{"nameIdentifier":"39699","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森田, 哲生"}],"nameIdentifiers":[{"nameIdentifier":"39700","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Heparin is known to stimulate the release of hepatic hpase (HTGL) activity from hepatocytes, but the action mechanisms have not been fully confirmed. Here, we investigated the involvement of the arachidonate pathway in the heparin-stimulated release of HGTL activity from rat hepatocytes. Heparin increased phospholipase (PL) A_2 activity in the hepatocytes in a time- and dose- dependent manner. The stimulatory effect of heparin on PLA_2 activity was markedly decreased by incubation with protein tyrosine kinase (TK) inhibitors. It was also observed that heparin rapidly increased leukotriene (LT) B_4 content in the hepatocytes. In addition, the stimulatory release of HTGL activity by heparin was suppressed by cytosolic PLA_2, and 5-lipoxygenase, but not by cyclooxygenase and thromboxane (TX) synthetase inhibitors or a TXA_2 receptor antagonist. These findings suggest that the heparin-stimulated release of HTGL activity from hepatocytes is partly due to an action involving increases in cytosolic PLA_2 activity and LTB_4 production with associated of TK activity.","subitem_description_type":"Other"}]},"item_1_full_name_7":{"attribute_name":"著者名よみ","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"39701","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タガシラ, ヒサシ"}]},{"nameIdentifiers":[{"nameIdentifier":"39702","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ケラカワチ, リエ"}]},{"nameIdentifiers":[{"nameIdentifier":"39703","nameIdentifierScheme":"WEKO"}],"names":[{"name":"モトヤシキ, トシオ"}]},{"nameIdentifiers":[{"nameIdentifier":"39704","nameIdentifierScheme":"WEKO"}],"names":[{"name":"モリタ, テツオ"}]}]},"item_1_full_name_8":{"attribute_name":"著者名(英)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"39705","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tagashira, Hisashi","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"39706","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kerakawati, Rie","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"39707","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Motoyashiki, Toshio","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"39708","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Morita, Tetsuo","nameLang":"en"}]}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Fukuyama University"},{"subitem_text_language":"en","subitem_text_value":"Fukuyama University"},{"subitem_text_language":"en","subitem_text_value":"Fukuyama University"},{"subitem_text_language":"en","subitem_text_value":"Fukuyama University"}]},"item_1_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_value":"総説"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"福山大学"},{"subitem_text_value":"福山大学"},{"subitem_text_value":"福山大学"},{"subitem_text_value":"福山大学"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2006-01-01"}],"displaytype":"detail","filename":"KJ00005784941.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://fukuyama-u.repo.nii.ac.jp/record/7328/files/KJ00005784941.pdf"},"version_id":"2fcc030b-4c6b-4368-b983-7a4b4843fb45"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"初代培養ラット肝細胞系における肝性リパーゼ放出機構の解析に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"初代培養ラット肝細胞系における肝性リパーゼ放出機構の解析に関する研究"},{"subitem_title":"The Stimulatory Release of Hepatic Lipase from Rat Cultured Hepatocytes","subitem_title_language":"en"}]},"item_type_id":"1","owner":"3","path":["651"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-01-01"},"publish_date":"2006-01-01","publish_status":"0","recid":"7328","relation_version_is_last":true,"title":["初代培養ラット肝細胞系における肝性リパーゼ放出機構の解析に関する研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T10:44:45.206687+00:00"}