@article{oai:fukuyama-u.repo.nii.ac.jp:00007243, author = {ウイナルノ, ヘンディック and 大橋, 一慶 and 澁谷, 博孝}, journal = {福山大学薬学部研究年報, Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University}, month = {}, note = {P(論文), Six fatty acids (1-6), two xanthines (7, 8), two flavonol glycosides (9, 10), one monoterpene glucoside (11), one lignan glycoside (12), and four flavanes (13-16) were clarified by a bioassay-guided separation as chemical constituents of Scurrula atropurpurea (Loranthaceae), a parasitic plant of the tea plant Thea sinensis (Theaceae). Among these constituents, it was found that the alkynic fatty acid octadeca-8,10,12-tnynoic acid (6) exhibits a more potent inhibitory effect on cancer cell invasion in vitro than flavanes [(+)-catechin (13), (-)-epicatechin (14), (-)-epicatechin-3-O-gallate (15) and (-)-epigallocatechin-3-O-gallate (16)]. Furthermore, five C16-alkynic fatty acids were prepared and examined their inhibitory effects on cancer cell invasion. It has been found that hexadeca-6,8,10-tnynoic acid (22) and hexadeca-8,10,12-tnynoic acid (23) exhibite similar potent inhibitory activities with octadeca-8,10,12-triynoic acid (6) which was isolated from Scurrula atropurpurea.}, pages = {13--29}, title = {インドネシア産ヤドリギ科植物Scurrula atropurpureaの化学的研究}, volume = {21}, year = {2003} }