@article{oai:fukuyama-u.repo.nii.ac.jp:00007140, author = {本屋敷, 敏雄 and 植木, 寛}, journal = {福山大学薬学部研究年報, Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University}, month = {}, note = {P(論文), Lipoprotein lipase (LPL) catalyzes the hydrolysis of plasma triglycerides and thereby regulates the uptake of their constituent fatty acids by tissues such as adipose tissue, cardiac and skeletal muscles, and mammary gland. Vanadium is an essential trace element for animals owing to its physiological and biochemical activities. Vanadium compounds mimic many in vitro and in vivo effects of insulin including the stimulation of glucose transport, the stimulatory phosphorylation of insulin receptor in isolated rat adipocytes, and the normalization of blood glucose levels of streptozotocin-induced diabetic rats. In this review, we found that vanadium compounds stimulates the release of LPL activity from isolated rat fat pads through a transient increase in cellular content of cAMP and myo-inositol 1,4,5-trisphosphate (1,4,5-IP_3), leading to an intracellular Ca^<2+> concentration.}, pages = {1--35}, title = {バナジウム化合物によるリポ蛋白質リパーゼ活性放出促進機構}, volume = {18}, year = {2000} }