@article{oai:fukuyama-u.repo.nii.ac.jp:00007136,
 author = {世良, 庄司 and 五郎丸, 毅 and 鮫島, 照子 and 川崎, 孝一 and 小田, 利通},
 journal = {福山大学薬学部研究年報, Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University},
 month = {},
 note = {P(論文), フェンタニル(FT)とその主代謝物Nor-FTの尿中濃度を重水素標識体(FT-^2H_<19>およびNor-FT-^2H_<10>)を用いた同位体希釈分析により測定した。表面電離型イオン化検出器装備キャピラリGCによりFTは0.4-40ng/ml、Nor-FTはN-メチル誘導体化後10-400ng/mlの範囲で再現性よく測定できた。, Isotope dilution analysis was applied to determine urinary excretion of fentanyl (FT) and its main metabolite, norfentanyl (Nor-FT), by isotopic fractionation using a capillary gas chromatograph equipped with a surface ionization detector (SID). Urinary FT was determined quantitatively in the range of 0.4-40 ng/ml using deuterium labeled FT (FT-2H19) , as an internal standard. Nor-FT concentration was quantitatively determined in the range of 10-400 ng/ml using deuterium labeled Nor-FT (Nor-FT-^2H_<10>). No endogenous compounds or concomitant drugs interfered with the detection of FT and Nor-FT in the urine of patients. The present method will be useful for pharmacokinetic studies and the evaluation of drug interactions in FT metabolism.},
 title = {キャピラリガスクロマトグラフィを用いた同位体希釈分析による患者尿中フェンタニルおよび主代謝物ノルフェンタニルの定量},
 volume = {17},
 year = {1999}
}