@article{oai:fukuyama-u.repo.nii.ac.jp:00007106, author = {八木, 晟 and 長尾, 美代子 and 岡村, 信幸 and 石津, 隆 and 伊藤, 洋 and 信太, 隆夫}, journal = {福山大学薬学部研究年報, Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University}, month = {}, note = {P(論文), ヒト胎盤水解物よりジペプチド(1)が収率0.011%で単離された。(1)の構造は物理・化学的方法によりcyclo(trans-4-L-Hydroxyprolyl-L-Serine)と決定された。(1)は12.5μg/mlの濃度で幼ハムスター腎細胞を133%増殖した。(1)と同時にuracilも単離され、12.5μg/mlの濃度で、同細胞を130%増殖した。(1)の構造は合成によって同定された。, A dipeptide isolated from the hydrolysate of human placenta in a yield of 0.011% and identified as cyclo(trans-4-L-Hydroxypolyl-L-Serine) on the basis of physico-chemical and HPLC examination showed a proliferation-promoting activity(% control:133) on baby hamster kidney-21/C-13 cells at a dose of 12.5 μg/ml. From the hydrolysate uracil was also isolated in a yield of 0.009 % and it also showed the proliferation-promoting activity(% control: 130) at a dose of 12.5 μg/ml. Synthesis of the cyclic dipeptide was performed by a modified method of Nitecki.}, title = {ヒト胎盤水解物よりサイクロジペプチドの単離と細胞(幼ハムスター腎)増殖活性}, volume = {17}, year = {1999} }