{"created":"2023-06-19T09:50:16.099465+00:00","id":7095,"links":{},"metadata":{"_buckets":{"deposit":"d0c67dfb-fddb-4a6b-bac8-98fcf8862025"},"_deposit":{"created_by":3,"id":"7095","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"7095"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00007095","sets":["502:503:627:643"]},"author_link":["36963","36970","36969","36960","36968","36965","36966","36971","36962","36964","36961","36967"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"91","bibliographicPageStart":"90","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"片山, 博和"}],"nameIdentifiers":[{"nameIdentifier":"36960","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石田, 浩"}],"nameIdentifiers":[{"nameIdentifier":"36961","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉富, 博則"}],"nameIdentifiers":[{"nameIdentifier":"36962","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅家, 甫子"}],"nameIdentifiers":[{"nameIdentifier":"36963","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"天然の疎水性蛋白質ゼインを用い、テオフィリン(T)含有の徐放性錠剤を作成し、in vitro及びin vivoでその有用性について評価した。ゼイン錠からのTの放出に対し、錠剤中の薬物量、溶出液中のペプシンは影響したが、溶出液のpHやパンクレアチンは影響しなかった。水溶性の色素(BB)を錠剤中あるいは溶出液に添加するとペプシンによる錠剤の消化が抑制され、Tの放出は抑えられた。健常人(4名)にゼイン錠を投与し、Tの唾液中濃度を測定したところ、T粉末、Tの徐放性市販錠とAUCはほぼ同じであった。MRTに関してはBBを含むゼイン錠が大きな値を示し、in vivoでもペプシンに対し抵抗性を示すものと考えられた。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"An application of zein, a water-insoluble corn protein, to sustained-release tablets was studied. It was found that the drug release from the tablets prepared from spray-dried particles of zein/theophylline/brilliant blue FCF (BB) was affected by drug amount in the tablets and pepsin in a release medium, but little by pH and pancreatin in the medium. The theophylline release was apparently zero-order in the relase medium containing pepsin probably due to the erosion of the tablets by the enzyme. The zein tablets containing BB were pepsin-resistance and the drug release was retarded. The addition of BB in the release medium also showed the same effect. Salivary concentrations of theophylline following oral administration of the drug powder, the zein tablets and a commercially obtained sustained-release tablet were determined in 4 male healthy volunteers. The dose-normalized AUCs of these theophylline preparations did not differ significantly, suggesting that the the extent of bioavailability of these preparations was much the same. The mean residence times (MRTs) of T41 tablet (pepsin-sensitive, zein:theophylline=4:1) were not different from those of the commercial tablets significantly. However, the MRTs of T41B1 tablet (pepsin-resistant, zein:theophylline:BB=4:1:0.1, 31.8 ± 9.0 h, mean ± SD, n=4) was significantly longer than that of T41 (20.9 ± 4.1 h, mean ± SD, n=4) (p < 0.05, paired t-test). T41B1 tablets might be pepsin-resistance even in vivo.","subitem_description_type":"Other"}]},"item_1_full_name_7":{"attribute_name":"著者名よみ","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"36964","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カタヤマ, ヒロカズ"}]},{"nameIdentifiers":[{"nameIdentifier":"36965","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イシダ, ヒロシ"}]},{"nameIdentifiers":[{"nameIdentifier":"36966","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヨシトミ, ヒロノリ"}]},{"nameIdentifiers":[{"nameIdentifier":"36967","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カンケ, モトコ"}]}]},"item_1_full_name_8":{"attribute_name":"著者名(英)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"36968","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Katayama, Hirokazu","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"36969","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ishida, Hiroshi","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"36970","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yoshitomi, Hironori","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"36971","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kanke, Motoko","nameLang":"en"}]}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"FACULTY OF PHARMACY & PHARMACEUTICAL SCIENCES FUKUYAMA UNIVERSITY"},{"subitem_text_language":"en","subitem_text_value":"FACULTY OF PHARMACY & PHARMACEUTICAL SCIENCES FUKUYAMA UNIVERSITY"},{"subitem_text_language":"en","subitem_text_value":"FACULTY OF PHARMACY & PHARMACEUTICAL SCIENCES FUKUYAMA UNIVERSITY"},{"subitem_text_language":"en","subitem_text_value":"FACULTY OF PHARMACY & PHARMACEUTICAL SCIENCES FUKUYAMA UNIVERSITY"}]},"item_1_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_value":"発表論文抄録"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"福山大学薬学部"},{"subitem_text_value":"福山大学薬学部"},{"subitem_text_value":"福山大学薬学部"},{"subitem_text_value":"福山大学薬学部"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1998-01-01"}],"displaytype":"detail","filename":"KJ00005784692.pdf","filesize":[{"value":"70.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://fukuyama-u.repo.nii.ac.jp/record/7095/files/KJ00005784692.pdf"},"version_id":"676a78ee-7085-4a63-8331-9da90d58cdac"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ゼインを用いた徐放性錠剤の調製と評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ゼインを用いた徐放性錠剤の調製と評価"},{"subitem_title":"Evaluation of zein tablets for sustained release dosage form in vitro and in vivo","subitem_title_language":"en"}]},"item_type_id":"1","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"1998-01-01"},"publish_date":"1998-01-01","publish_status":"0","recid":"7095","relation_version_is_last":true,"title":["ゼインを用いた徐放性錠剤の調製と評価"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T10:50:30.859382+00:00"}