{"created":"2023-06-19T09:50:15.931004+00:00","id":7091,"links":{},"metadata":{"_buckets":{"deposit":"cbbc4568-2497-4e1e-bc15-d0f3cfacc9cc"},"_deposit":{"created_by":3,"id":"7091","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"7091"},"status":"published"},"_oai":{"id":"oai:fukuyama-u.repo.nii.ac.jp:00007091","sets":["502:503:627:643"]},"author_link":["36898","36897","36902","36907","36899","36903","36905","36908","36904","36900","36906","36901"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"85","bibliographicPageStart":"84","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"福山大学薬学部研究年報"},{"bibliographic_title":"Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"金尾, 義治"}],"nameIdentifiers":[{"nameIdentifier":"36897","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上村, 智哉"}],"nameIdentifiers":[{"nameIdentifier":"36898","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 哲郎"}],"nameIdentifiers":[{"nameIdentifier":"36899","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加納, 聰"}],"nameIdentifiers":[{"nameIdentifier":"36900","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"分子量の異なるフルオレセイン標識デキストラン(FD)のマウスにおける体内動態を評価した.分子量20kDa未満のFDは血中から速やかに消失し,肝への分布は低かった.より高い分子量をもつFDは顕著に肝へ分布し,長期にわたって蓄積した.肝平均滞留時間は22.5～28.1日であった.肝に蓄積したFDの一部は低分子化を受けた.肝取込みクリアランスは分子量の増加に伴って減少した.尿中並びに糞便中排泄にも顕著な分子量依存性が認められた.肝取込みには顕著な投与量依存性が観察された.みかけのKm(投与量)とVmax(肝臓のレベル)の値は,それぞれ116±5mg/kg並びに1.10±0.05mg/g tissueと算出された.","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"The biodisposition of fluorescein-labeled dextrans (FDs) with different molecular weights (MW = 4-500 kDa) was systematically examined in mice. After intravenous injection of FDs at a dose of 120 mg/kg, the levels of FDs in the blood circulation and in the various organs were measured fluorometrically. FDs with a molecular weight lower than 20 kDa showed poor hepatic distribution (2.1-3.7 % of dose/g tissue) due to their rapid elimination from the blood circulation. FDs with higher molecular weights were appreciably distributed in the liver (18.9-24.0 % of dose/g tissue) and accumulated there over a long period, whereas the FD levels in the other organs were almost negligible a few days after injection. The hepatic mean residence time of FDs ranged from 22.5 to 28.1 d. Partial depolymerization of FDs which accumulated in the liver was observed within 10 d after administration. The hepatic uptake clearance of FDs was decreased with an increase in molecular weight. A marked molecular weight dependency was also seen in the urinary and fecal excretions of FDs. An appreciable dose-dependency was demonstrated in the hepatic uptake of FDs (MW = 40 kDa) , as well. The amount of hepatic uptake as a function of dose showed saturation kinetics and was analyzed by a Michaelis-Menten type equation. The apparent values of Km (dose) and Vmax (hepatic level) estimated were 116 ± 5 mg/kg and 1.10 ± 0.05 mg/g tissue, respectively.","subitem_description_type":"Other"}]},"item_1_full_name_7":{"attribute_name":"著者名よみ","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"36901","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カネオ, ヨシハル"}]},{"nameIdentifiers":[{"nameIdentifier":"36902","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ウエムラ, トモチカ"}]},{"nameIdentifiers":[{"nameIdentifier":"36903","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タナカ, テツロウ"}]},{"nameIdentifiers":[{"nameIdentifier":"36904","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カノウ, サトシ"}]}]},"item_1_full_name_8":{"attribute_name":"著者名(英)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"36905","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kaneo, Yoshiharu","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"36906","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Uemura, Tomochika","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"36907","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tanaka, Tetsuro","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"36908","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kanoh, Satoshi","nameLang":"en"}]}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN10064550","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"FACULTY OF PHARMACY & PHARMACEUTICAL SCIENCES FUKUYAMA UNIVERSITY"},{"subitem_text_language":"en","subitem_text_value":"FACULTY OF PHARMACY & PHARMACEUTICAL SCIENCES FUKUYAMA UNIVERSITY"},{"subitem_text_language":"en","subitem_text_value":"FACULTY OF PHARMACY & PHARMACEUTICAL SCIENCES FUKUYAMA UNIVERSITY"},{"subitem_text_language":"en","subitem_text_value":"FACULTY OF PHARMACY & PHARMACEUTICAL SCIENCES FUKUYAMA UNIVERSITY"}]},"item_1_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_value":"発表論文抄録"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"福山大学薬学部"},{"subitem_text_value":"福山大学薬学部"},{"subitem_text_value":"福山大学薬学部"},{"subitem_text_value":"福山大学薬学部"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1998-01-01"}],"displaytype":"detail","filename":"KJ00005784688.pdf","filesize":[{"value":"71.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://fukuyama-u.repo.nii.ac.jp/record/7091/files/KJ00005784688.pdf"},"version_id":"340530eb-98b1-459e-8b8d-2b2a4f893bc9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"薬物担体としての多糖類 : フルオレセイン標識デキストランのマウスにおける体内動態","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"薬物担体としての多糖類 : フルオレセイン標識デキストランのマウスにおける体内動態"},{"subitem_title":"Polysaccharides as Drug Carriers : Biodisposition of Fluorescein-Labeled Dextrans in Mice","subitem_title_language":"en"}]},"item_type_id":"1","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"1998-01-01"},"publish_date":"1998-01-01","publish_status":"0","recid":"7091","relation_version_is_last":true,"title":["薬物担体としての多糖類 : フルオレセイン標識デキストランのマウスにおける体内動態"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T10:50:26.414731+00:00"}