@article{oai:fukuyama-u.repo.nii.ac.jp:00007079, author = {小林, 資正 and マハムド, タイフォー and 吉岡, 直樹 and 澁谷, 博孝 and 北川, 勲}, journal = {福山大学薬学部研究年報, Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University}, month = {}, note = {P(論文), インドネシアの薬用植物であるErythrina variegata樹皮およびMacluracochinchinensis根からerythrinin B,euchrenone b_<10>,及び1,3,5-trihydroxy-4-(3-methylbut-2-enyl)xanthen-9-oneを単離し、それぞれに1.25,1.25,10μg/mlの濃度でNa^+/H^+交換阻害活性があることを明らかにした。さらに、M.cochinchinensis根から3種の新規プレニルキサントン、isocudraniaxanthones B,A及びisoalvaxanthoneを単離し、それらの化学構造を化学的及び物理化学的手法を用いて明らかにした。, Through bioassay-guided separation of the methanol extracts of Indonesian medicinal plants, three inhibitors of the Na^+/H^+ exchange system, erythrinin B, euchrenone b10, and 1,3,5-trihydroxy-4-(3-methylbut-2-enyl) xanthen-9-one, were isolated from the bark of Erythrina variegata (Fabaceae) and the roots of Maclura cochinchinensis (Moraceae). These compounds significantly inhibited the Na^+/H^+ exchange system of arterial smooth muscle cells, with minimum inhibitory concentrations of 1.25, 1.25, and 10 μg/ml, respectively. Three new prenylated xanthones named isocudraniaxanthones B and A and isoalvaxanthone were also isolated from M. cochinchinensis and the chemical structures were elucidated on the bases of their chemical and physicochemical properties.}, pages = {63--64}, title = {インドネシア薬用植物第XXI報 : Erythrina variegata樹皮とMaclura cochinchinensis根から単離したNa+/H+交換阻害物質}, volume = {16}, year = {1998} }