@article{oai:fukuyama-u.repo.nii.ac.jp:00006981, author = {石津, 隆 and 野口, 俊作}, journal = {福山大学薬学部研究年報, Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University}, month = {}, note = {P(論文), We have been attempting to synthesize the peptide which is possible to recognize effectively l-noradrenaline like a adrenoreceptor. For the purpose the cyclooctapeptide having a ligid skeleton, cyclo(L-Phe-L-Pro)_4 was investigated to form the complex with some catecholamines and aromatic amino acids which are the precursors of adrenaline in the biosynthetic pathway (Chart 1). The resulted compexes of cyclo(L-Phe-L-Pro)_4 with them were formed by the force of one or two kinds of the hydrogen bond and the interaction of the pirrolidine ring of Pro^2 residue with their aromatic rings. The enantioselectivity of cyclo(L-Phe-L-Pro)_4 in the complex formation was also investigated.}, pages = {24--43}, title = {環状オクタペプチドによる芳香族アミノ酸およびカテコールアミン類の分子認識}, volume = {14}, year = {1996} }