@article{oai:fukuyama-u.repo.nii.ac.jp:00006874,
 author = {杉原, 成美 and 古野, 浩二},
 journal = {福山大学薬学部研究年報, Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University},
 month = {},
 note = {P(論文), There has been little information on the disposition of weak basic drugs in either patients or experimental model animals with hepatic disease. We have investigated the last few years the influence of liver injury on plasma pharmaco- kinetic and physiological parameters for quinidine in carbon tetrachloride-intoxicated rats. The systematic analysis on the alteration of such parameters for quinidine revealed that the increase in the plasma protein binding of the drug as well as the reduction of liver functions played the important role in the drug disposition. The increased protein binding of the drug in the blood was attributed to the rise in the plasma α_1-acid glycoprotein concentration, which has been found to occur as an acute phase reaction in response to various pathophysiological conditions. Lastly, the sole effect of the elevation of the plasma concentration of α_1-acid glycoprotein on the disposition of quinidine was also studied in turpentine-treated rats without any hepatic dysfunction.},
 pages = {15--42},
 title = {薬物性肝障害ラットにおける弱塩基性薬物の体内動態変動の機序 : 血漿α_1酸性糖蛋白質の影響を中心にして},
 volume = {12},
 year = {1994}
}