@article{oai:fukuyama-u.repo.nii.ac.jp:00006433, author = {日比野, 俐}, journal = {福山大学薬学部研究年報, Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University}, month = {}, note = {P(論文), Streptorugrin (1) is produced from cultures of Streptomyces flocculus, which is of interest as a potential antitumor antibiotic agent since it exhibits a broad spectrum of inhibition of various bacterias and tumors. Dunng the last twenty five years streptonigrin (1) has been the subject of intensive study regarding its use as an anticancer drug, its cytotoxic mechanism of action, its laboratory synthesis, and its biosynthesis. On the other hand, a new metabolite which is closely related to streptonigrin (1) has recently been isolated from Streptomyces lavendulae and has been named lavendamycin (2). The present review contents isolation and structure determination, total synthesis, and biological study including structure activity relation.}, pages = {92--111}, title = {ストレプトニグリンとラベンダマイシン(福山大学開学10周年記念号)}, volume = {3}, year = {1985} }