@article{oai:fukuyama-u.repo.nii.ac.jp:00006368,
 author = {吉柳, 節夫 and 立山, 正 and 井口, 定男},
 journal = {福山大学薬学部研究年報, Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University},
 month = {},
 note = {P(論文), 薬物の吸収あるいは生体内移行の基本的な素過程である水相-無極性液相間の界面透過過程については薬剤学的にも多くの理論的,実験的検討が行われている.しかし溶液中での2種の薬物の複合体形成とこの過程との関連について検討した例は少ない.そこで水相,ベンゼン相のいずれにおいても複合体を形成するバルビタール-アミノピリン系を用いて,バルビタールの界面透過速度におよぼす複合体形成の効果を検討した., The effect of complex formation on the water-benzene interfacial transfer rate of barbital was studied. The transfer rate of barbital from aqueous to benzene phase was much accelerated by the addition of aminopyrine. The association constants of 1:1 barbital-aminopyrine complex in both phases were determined by solubility method. The constants in benzene and aqueous solutions at 30℃ were 22.1 and 2.24 M^<-1>, respectively. The best fitting equations for transfer data were numerically analyzed and it was clarified that the time course of the transfer rate of the complex was similar to that of free barbital and that the large value of the association constant in benzene solution resulted in the large transfer rate constant of the complex.},
 pages = {1--4},
 title = {薬物の2液相間移行速度におよぼす複合体形成の効果},
 volume = {1},
 year = {1982}
}