2026-03-08T07:25:57Z https://fukuyama-u.repo.nii.ac.jp/oai

oai:fukuyama-u.repo.nii.ac.jp:00008760 2023-06-19T10:17:32Z 502:503:627:783

Calothrixins A、BとそのN-アルキル置換誘導体の合成と抗マラリア活性(発表論文抄録(2012)) Synthesis and antimalarial activity of calothrixins A and B, and their N-alkyl derivatives. Matsumoto, Kohji 45787 Choshi, Tominari 45788 Hourai, Mai 45789 Zamami, Yoshito 45790 Sasaki, Kenji 45791 Abe, Takumi 45792 Ishikura, Minoru 45793 Hatae, Noriyuki 45794 Iwamura, Tatsunori 45795 Tohyama, Shigeo 45796 Nobuhiro, Junko 45797 Hibino, Satoshi 45798 Alkylation Antimalarials Indole Alkaloids Molecular Structure Plasmodium falciparum Structure-Activity Relationship We synthesized calothrixin B using our developed biomimetic method and derived N-alkyl-calothrixins A and B. The in vitro antimalarial activity of the calothrixin derivatives, including calothrixins A and B, against the Plasmodium falciparum FCR-3 strain was evaluated. All test compounds exhibited antimalarial activity over a concentration range of 6.4×10(-6)-1.2×10(-7) M. We synthesized calothrixin B using our developed biomimetic method and derived N-alkyl-calothrixins A and B. The in vitro antimalarial activity of the calothrixin derivatives, including calothrixins A and B, against the Plasmodium falciparum FCR-3 strain was evaluated. All test compounds exhibited antimalarial activity over a concentration range of 6.4×10(-6)-1.2×10(-7) M. departmental bulletin paper 福山大学薬学部 2013-12-25 application/pdf 福山大学薬学部研究年報 31 22 22 Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University AN10064550 0288-724X https://fukuyama-u.repo.nii.ac.jp/record/8760/files/31-22.pdf https://fukuyama-u.repo.nii.ac.jp/records/8760 eng