2026-03-08T17:25:20Z https://fukuyama-u.repo.nii.ac.jp/oai

oai:fukuyama-u.repo.nii.ac.jp:00007141 2023-06-19T10:48:23Z 502:503:627:645

インドネシア薬用植物クミスクチン葉の化学的研究 Chemical Study on the Leaves of Kumis kucing, an Indonesian Medicinal Plant 坊垣, 貴子 37476 大橋, 一慶 37477 澁谷, 博孝 37478 P(論文) The water decoction of the leaves of kumis kucing, Orthosiphon aristatus (B_L.) M_<IQ>. (Lamiaceae) which has been prescribed in Javanese traditional medicine (jamu) for the treatment of hypertension etc., was partitioned into a mixture of chloroform and water. The chloroform-soluble portion showed an inhibitory effect on the contractile responses on rat thoracic aorta smooth muscle stimulated with KCl beforehand, while the water-soluble portion did not show the effect. The chloroform-soluble portion was separated to afford a new benzochromene [orthochromene A (7)], two new isopimarane-type diterpenes [orthosiphonone A (10), orthosiphonone B (11)], and two novel migrated pimarane-type diterpenes [neoorthosiphol A (12), neoorthosiphol B (13)], together with eight known compounds (1-6, 8, 9). Among those thirteen substances, it was found that the major constituent in the water decoction of the leaves, methylripariochromene A (5), exhibited the continuous decrease in systolic blood pressure after subcutaneous administration in conscious SHRSP. departmental bulletin paper 2000 application/pdf 福山大学薬学部研究年報 18 36 51 Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University AN10064550 https://fukuyama-u.repo.nii.ac.jp/record/7141/files/KJ00005784742.pdf https://fukuyama-u.repo.nii.ac.jp/records/7141 jpn