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エンドセリン-1 によるエールリッヒ腹水癌細胞からのリポタンパク質リパーゼの分泌(発表論文抄録(2010))
https://fukuyama-u.repo.nii.ac.jp/records/8834
https://fukuyama-u.repo.nii.ac.jp/records/8834e5d78710-064b-48a5-a98a-b49108aa64c6
名前 / ファイル | ライセンス | アクション |
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螻川内理恵(発表論文抄録(2010)) (588.0 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-12-27 | |||||
タイトル | ||||||
タイトル | エンドセリン-1 によるエールリッヒ腹水癌細胞からのリポタンパク質リパーゼの分泌(発表論文抄録(2010)) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Endothelin-1 Stimulates Secretion of Lipoprotein Lipase from Ehrlich Ascites Tumor Cells | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | lipoprotein lipase | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | endothelin-1 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | endothelin receptor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Ehrlich ascites tumor | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Kerakawati, Rie
× Kerakawati, Rie× Morita, Tetsuo |
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著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 45184 | |||||
識別子Scheme | CiNii ID | |||||
識別子URI | http://ci.nii.ac.jp/nrid/9000014625914 | |||||
識別子 | 9000014625914 | |||||
姓名 | 螻川内, 理恵 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 45181 | |||||
識別子Scheme | CiNii ID | |||||
識別子URI | http://ci.nii.ac.jp/nrid/9000005151603 | |||||
識別子 | 9000005151603 | |||||
姓名 | 森田, 哲生 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Since the role of endothelin (ET)-1 in lipoprotein metabolism in tumor cells is unclear, we investigated the effect of ET-1 on the secretion of lipoprotein lipase (LPL) from mouse Ehrlich ascites tumor cells. ET-1 increased the secretion of LPL from these cells in a time-dependent manner. Two antagonists of ET-receptor type A (ET-A), namely, BQ123 and FR139317, inhibited the stimulatory effect of ET-1 on the secretion of LPL. However, an antagonist of ET-receptor type B (ET-B), BQ788, did not have any effect. Neomycin, a phospholipase C (PLC) inhibitor, and H-7, a protein kinase C (PKC) inhibitor, also suppressed the ET-1-stimulated secretion of LPL. ET-1 also increased PKC activity in tumor cells in a dose-dependent manner. These results imply that ET-1 stimulates secretion of LPL from tumor cells by stimulating the PLC-PKC signaling pathway through the ET-A receptor rather than the ET-B receptor. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Since the role of endothelin (ET)-1 in lipoprotein metabolism in tumor cells is unclear, we investigated the effect of ET-1 on the secretion of lipoprotein lipase (LPL) from mouse Ehrlich ascites tumor cells. ET-1 increased the secretion of LPL from these cells in a time-dependent manner. Two antagonists of ET-receptor type A (ET-A), namely, BQ123 and FR139317, inhibited the stimulatory effect of ET-1 on the secretion of LPL. However, an antagonist of ET-receptor type B (ET-B), BQ788, did not have any effect. Neomycin, a phospholipase C (PLC) inhibitor, and H-7, a protein kinase C (PKC) inhibitor, also suppressed the ET-1-stimulated secretion of LPL. ET-1 also increased PKC activity in tumor cells in a dose-dependent manner. These results imply that ET-1 stimulates secretion of LPL from tumor cells by stimulating the PLC-PKC signaling pathway through the ET-A receptor rather than the ET-B receptor. | |||||
書誌情報 |
福山大学薬学部研究年報 en : Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University 号 29, p. 42-42, 発行日 2012-12-25 |
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出版者 | ||||||
出版者 | 福山大学薬学部 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0288-724X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10064550 |