WEKO3
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キャピラリガスクロマトグラフィを用いた同位体希釈分析による患者尿中フェンタニルおよび主代謝物ノルフェンタニルの定量
https://fukuyama-u.repo.nii.ac.jp/records/7136
https://fukuyama-u.repo.nii.ac.jp/records/71369dcb3ef2-c969-40a1-8979-c03f23fdea66
名前 / ファイル | ライセンス | アクション |
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KJ00005784735.pdf (46.0 kB)
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 1999-01-01 | |||||
タイトル | ||||||
タイトル | キャピラリガスクロマトグラフィを用いた同位体希釈分析による患者尿中フェンタニルおよび主代謝物ノルフェンタニルの定量 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Isotope Dilution Analysis for Urinary Fentanyl and its Main Metabolite, Norfentanyl, in Patients by Isotopic Fractionation using Capillary Gas Chromatography | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
記事種別(日) | ||||||
値 | 発表論文抄録 | |||||
著者名(日) |
世良, 庄司
× 世良, 庄司× 五郎丸, 毅× 鮫島, 照子× 川崎, 孝一× 小田, 利通 |
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著者名よみ | ||||||
識別子Scheme | WEKO | |||||
識別子 | 37460 | |||||
姓名 | セラ, ショウジ | |||||
著者名よみ | ||||||
識別子Scheme | WEKO | |||||
識別子 | 37461 | |||||
姓名 | ゴロウマル, ツヨシ | |||||
著者名よみ | ||||||
識別子Scheme | WEKO | |||||
識別子 | 37462 | |||||
姓名 | サメジマ, テルコ | |||||
著者名よみ | ||||||
識別子Scheme | WEKO | |||||
識別子 | 37463 | |||||
姓名 | カワサキ, コウイチ | |||||
著者名よみ | ||||||
識別子Scheme | WEKO | |||||
識別子 | 37464 | |||||
姓名 | オダ, トシユキ | |||||
著者名(英) | ||||||
識別子Scheme | WEKO | |||||
識別子 | 37465 | |||||
姓名 | Sera, Shoji | |||||
言語 | en | |||||
著者名(英) | ||||||
識別子Scheme | WEKO | |||||
識別子 | 37466 | |||||
姓名 | Goromaru, Tsuyoshi | |||||
言語 | en | |||||
著者名(英) | ||||||
識別子Scheme | WEKO | |||||
識別子 | 37467 | |||||
姓名 | Sameshima, Teruko | |||||
言語 | en | |||||
著者名(英) | ||||||
識別子Scheme | WEKO | |||||
識別子 | 37468 | |||||
姓名 | Kawasaki, Koichi | |||||
言語 | en | |||||
著者名(英) | ||||||
識別子Scheme | WEKO | |||||
識別子 | 37469 | |||||
姓名 | Oda, Toshiyuki | |||||
言語 | en | |||||
著者所属(日) | ||||||
値 | 福山大学薬学部 | |||||
著者所属(日) | ||||||
値 | 福山大学薬学部 | |||||
著者所属(日) | ||||||
値 | 鹿児島大学医学部 | |||||
著者所属(日) | ||||||
値 | 鹿児島大学医学部 | |||||
著者所属(日) | ||||||
値 | 鹿児島大学医学部 | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | FACULTY OF PHARMACY & PHARMACEUTICAL SCIENCES FUKUYAMA UNIVERSITY | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | FACULTY OF PHARMACY & PHARMACEUTICAL SCIENCES FUKUYAMA UNIVERSITY | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Kagoshima University Faculty of Medicine | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Kagoshima University Faculty of Medicine | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Kagoshima University Faculty of Medicine | |||||
抄録(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | フェンタニル(FT)とその主代謝物Nor-FTの尿中濃度を重水素標識体(FT-^2H_<19>およびNor-FT-^2H_<10>)を用いた同位体希釈分析により測定した。表面電離型イオン化検出器装備キャピラリGCによりFTは0.4-40ng/ml、Nor-FTはN-メチル誘導体化後10-400ng/mlの範囲で再現性よく測定できた。 | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Isotope dilution analysis was applied to determine urinary excretion of fentanyl (FT) and its main metabolite, norfentanyl (Nor-FT), by isotopic fractionation using a capillary gas chromatograph equipped with a surface ionization detector (SID). Urinary FT was determined quantitatively in the range of 0.4-40 ng/ml using deuterium labeled FT (FT-2H19) , as an internal standard. Nor-FT concentration was quantitatively determined in the range of 10-400 ng/ml using deuterium labeled Nor-FT (Nor-FT-^2H_<10>). No endogenous compounds or concomitant drugs interfered with the detection of FT and Nor-FT in the urine of patients. The present method will be useful for pharmacokinetic studies and the evaluation of drug interactions in FT metabolism. | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10064550 | |||||
書誌情報 |
福山大学薬学部研究年報 en : Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University 巻 17, p. 96, 発行日 1999 |