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薬物担体としての多糖類 : フルオレセイン標識デキストランのマウスにおける体内動態
https://fukuyama-u.repo.nii.ac.jp/records/7091
https://fukuyama-u.repo.nii.ac.jp/records/7091718a09c1-f6e4-4458-bb7f-260ba052c6d5
名前 / ファイル | ライセンス | アクション |
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KJ00005784688.pdf (71.9 kB)
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 1998-01-01 | |||||
タイトル | ||||||
タイトル | 薬物担体としての多糖類 : フルオレセイン標識デキストランのマウスにおける体内動態 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Polysaccharides as Drug Carriers : Biodisposition of Fluorescein-Labeled Dextrans in Mice | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
記事種別(日) | ||||||
値 | 発表論文抄録 | |||||
著者名(日) |
金尾, 義治
× 金尾, 義治× 上村, 智哉× 田中, 哲郎× 加納, 聰 |
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著者名よみ | ||||||
識別子Scheme | WEKO | |||||
識別子 | 36901 | |||||
姓名 | カネオ, ヨシハル | |||||
著者名よみ | ||||||
識別子Scheme | WEKO | |||||
識別子 | 36902 | |||||
姓名 | ウエムラ, トモチカ | |||||
著者名よみ | ||||||
識別子Scheme | WEKO | |||||
識別子 | 36903 | |||||
姓名 | タナカ, テツロウ | |||||
著者名よみ | ||||||
識別子Scheme | WEKO | |||||
識別子 | 36904 | |||||
姓名 | カノウ, サトシ | |||||
著者名(英) | ||||||
識別子Scheme | WEKO | |||||
識別子 | 36905 | |||||
姓名 | Kaneo, Yoshiharu | |||||
言語 | en | |||||
著者名(英) | ||||||
識別子Scheme | WEKO | |||||
識別子 | 36906 | |||||
姓名 | Uemura, Tomochika | |||||
言語 | en | |||||
著者名(英) | ||||||
識別子Scheme | WEKO | |||||
識別子 | 36907 | |||||
姓名 | Tanaka, Tetsuro | |||||
言語 | en | |||||
著者名(英) | ||||||
識別子Scheme | WEKO | |||||
識別子 | 36908 | |||||
姓名 | Kanoh, Satoshi | |||||
言語 | en | |||||
著者所属(日) | ||||||
値 | 福山大学薬学部 | |||||
著者所属(日) | ||||||
値 | 福山大学薬学部 | |||||
著者所属(日) | ||||||
値 | 福山大学薬学部 | |||||
著者所属(日) | ||||||
値 | 福山大学薬学部 | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | FACULTY OF PHARMACY & PHARMACEUTICAL SCIENCES FUKUYAMA UNIVERSITY | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | FACULTY OF PHARMACY & PHARMACEUTICAL SCIENCES FUKUYAMA UNIVERSITY | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | FACULTY OF PHARMACY & PHARMACEUTICAL SCIENCES FUKUYAMA UNIVERSITY | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | FACULTY OF PHARMACY & PHARMACEUTICAL SCIENCES FUKUYAMA UNIVERSITY | |||||
抄録(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 分子量の異なるフルオレセイン標識デキストラン(FD)のマウスにおける体内動態を評価した.分子量20kDa未満のFDは血中から速やかに消失し,肝への分布は低かった.より高い分子量をもつFDは顕著に肝へ分布し,長期にわたって蓄積した.肝平均滞留時間は22.5~28.1日であった.肝に蓄積したFDの一部は低分子化を受けた.肝取込みクリアランスは分子量の増加に伴って減少した.尿中並びに糞便中排泄にも顕著な分子量依存性が認められた.肝取込みには顕著な投与量依存性が観察された.みかけのKm(投与量)とVmax(肝臓のレベル)の値は,それぞれ116±5mg/kg並びに1.10±0.05mg/g tissueと算出された. | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | The biodisposition of fluorescein-labeled dextrans (FDs) with different molecular weights (MW = 4-500 kDa) was systematically examined in mice. After intravenous injection of FDs at a dose of 120 mg/kg, the levels of FDs in the blood circulation and in the various organs were measured fluorometrically. FDs with a molecular weight lower than 20 kDa showed poor hepatic distribution (2.1-3.7 % of dose/g tissue) due to their rapid elimination from the blood circulation. FDs with higher molecular weights were appreciably distributed in the liver (18.9-24.0 % of dose/g tissue) and accumulated there over a long period, whereas the FD levels in the other organs were almost negligible a few days after injection. The hepatic mean residence time of FDs ranged from 22.5 to 28.1 d. Partial depolymerization of FDs which accumulated in the liver was observed within 10 d after administration. The hepatic uptake clearance of FDs was decreased with an increase in molecular weight. A marked molecular weight dependency was also seen in the urinary and fecal excretions of FDs. An appreciable dose-dependency was demonstrated in the hepatic uptake of FDs (MW = 40 kDa) , as well. The amount of hepatic uptake as a function of dose showed saturation kinetics and was analyzed by a Michaelis-Menten type equation. The apparent values of Km (dose) and Vmax (hepatic level) estimated were 116 ± 5 mg/kg and 1.10 ± 0.05 mg/g tissue, respectively. | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10064550 | |||||
書誌情報 |
福山大学薬学部研究年報 en : Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University 巻 16, p. 84-85, 発行日 1998 |